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RO2959 monohydrochloride

Cat. No.: DC40200

Chemical Structure

2309172-44-7

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Field of application

RO2959 monohydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 monohydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC50 of 25 nM. RO2959 monohydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways.

Chemicals Properties Biological activity COA & MSDS Related products Datasheet

Cas No.:	2309172-44-7
Chemical Name:	RO2959 monohydrochloride
SMILES:	O=C(NC1=NC=C(C2=C(C)CCN(C3=NC=C(C)S3)C2)N=C1)C4=C(F)C=CC=C4F.[H]Cl
Formula:	C₂₁H₂₀ClF₂N₅Os
M.Wt:	463.93
Sotrage:	Please store the product under the recommended conditions in the Certificate of Analysis.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC40200	RO2959 monohydrochloride	RO2959 monohydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 monohydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC50 of 25 nM. RO2959 monohydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways.

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