Ralfinamide|cas 202825-45-4|DC Chemicals

Cas No.:	202825-45-4
Chemical Name:	(S)-2-((4-((2-Fluorobenzyl)oxy)benzyl)amino)propanamide methanesulfonate
Synonyms:	(S)-2-((4-((2-Fluorobenzyl)oxy)benzyl)amino)propanamide methanesulfonate;Ralfinamide Mesylate;(S)-2-((4-((2-Fluorobenzyl)oxy)benzyl)amino)propamide methanesulfote;(S)-2-((4-((2-Fluorobenzyl)oxy)benzyl)-amino)propanamide methanesulfonate;(2S)-2-[[[4-[(2-FLUOROPHENYL)METHOXY]PHENYL]METHYL]AMINO]-PROPANAMIDE METHANESULFONATE;AK102560;ANW-62015;CTK8B9097;KB-03700
SMILES:	C[C@H](NCC1=CC=C(OCC2=CC=CC=C2F)C=C1)C(N)=O.CS(=O)(O)=O
Formula:	C₁₇H₁₉N₂O₂F^.CH₄O₃S
M.Wt:	398.44902
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Selective Na+ blocker. Suppresses tetrodotoxin-resistant Na+ currents. Shows antiparkinsonian, antinociceptive and potent anticonvulsant effects in vivo. Orally active.For the detailed information of Ralfinamide, the solubility of Ralfinamide in water, the solubility of Ralfinamide in DMSO, the solubility of Ralfinamide in PBS buffer, the animal experiment (test) of Ralfinamide, the cell expriment (test) of Ralfinamide, the in vivo, in vitro and clinical trial test of Ralfinamide, the EC50, IC50,and Affinity of Ralfinamide, Please contact DC Chemicals.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC73683	LTGO-33	LTGO-33 is a potent, selective inhibitor of voltage-gated sodium channel NaV1.8 with IC50 of 44 nM (hNaV1.8), 600-fold selectivity against NaV1.1-NaV1.7 and NaV1.9.
DC70805	SSCI-2	SSCI-2 is a highly potent, selective NaV1.7 inhibitor with IC50 of 9 and 17 nM on human and rhesus Nav1.7 channels, respectively.SSCI-2 showed robust selectivity over other human and rhesus Nav channel paralogs, with the exception of Nav1.2 channels (IC50 183 nM for hNaV1.2), shows no other channels and receptors in 114 enzymatic, radioligand binding, and cellular assays.SSCI-2 also exhibits high potency in manual patch clamp experiments (IC50=24/62 nM for huma/rhesus Nav1.7 channels).SSCI-2 inhibits withdrawal responses to noxious heat in rhesus monkeys.
DC70247	BI 1265162	BI 1265162 is a potent ENaC inhibitor, inhibits Na+ transport with IC50 3 nM and 8 nM in M1 and NCI-H441 cells, respectively.BI 1265162 dose-dependently inhibited Na+ transport and decreased water resorption in cell line models.BI 1265162 reduced liquid absorption in rat lungs and increased MCC in sheep, with no effects on renal function in the animal models.BI 1265162 alone and in combination with CF transmembrane conductance regulator (CFTR) modulators decreased water transport and increased MCC in both normal and CF airway human epithelial models.
DC48532	Tocainide	Tocainide hydrochloride is an orally activesodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus.
DC47939	NBI-921352	NBI921352 is a Nav1.6 inhibitor with an IC50 value of 3.765 μM.
DC7287	Ralfinamide	Sodium channel blocker. Suppresses tetrodotoxin (TTX)-resistant Na+ currents approximately twice as selectively as TTX-sensitive currents. Antinociceptive; displays analgesic effects in animal models of inflammatory and neuropathic pain.
DC9623	Flecainide (acetate)	Flecainide(Tambocor) is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
DC11649	Jamaicin (AnCoA4)	AnCoA4 (AnCoA-4, AnCoA 4) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM.
DC9624	Sparteine sulfate pentahydrate	(-)-Sparteine sulfate pentahydrate is a class 1a antiarrhythmic agent and a sodium channel blocker.