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Home > Inhibitors & Agonists > GPCR > Histamine Receptor

S38093 HCl

  Cat. No.:  DC11271   Featured
Chemical Structure
1222097-72-4
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More than 5000 active chemicals with high quality for research!
Field of application
S 38093 is a novel brain-penetrant antagonist/inverse agonist of H3 receptors.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1222097-72-4
Synonyms: S 38093; S38093; S-38093; S38093 HCl
SMILES: O=C(N)C(C=C1)=CC=C1OCCCN2CC3CCCC3C2.Cl
Formula: C17H25ClN2O2
M.Wt: 324.16
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: S 38093 is a novel brain-penetrant antagonist/inverse agonist of H3 receptors.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC70655 NLX-204 NLX-204 is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist with pKi = 10.19. NLX-204 displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein. Preliminary in vivo studies confirmed its promising pharmacokinetic profile. NLX-204 also robustly stimulated ERK1/2 phosphorylation in rat cortex and showed highly potent (MED = 0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test.
DC10136 VUF10460 VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46.
DC11271 S38093 HCl S 38093 is a novel brain-penetrant antagonist/inverse agonist of H3 receptors.
DC9465 Pitolisant (hydrochloride) Pitolisant Hcl(BF2.649;Ciproxidine ) is a novel, potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor (Ki=0.16 nM).
DC8773 JNJ-7777120 JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.
DC10102 GSK189254A GSK189254A (GSK189254) is a novel, potent and selective histamine H3 receptor antagonist with pKi values of 9.59-9.90 and 8.51-9.17 for human and rat H3, respectively.
DC7995 Bilastine Bilastine is a selective histamine H1 receptor antagonist used for treatment of allergic rhinoconjunctivitis and urticaria.
DCAPI1500 Bepotastine Besilate Bepotastine Beslilate (Bepreve) is a histamine H1 receptor anatagonist.
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