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Home > Inhibitors & Agonists > Metabolic Enzyme/Protease > Phosphodiesterase (PDE)

SEP-0372814

  Cat. No.:  DC8048   Featured
Chemical Structure
1516895-53-6
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More than 5000 active chemicals with high quality for research!
Field of application
SEP-0372814 is a potent PDE10 inhibitor.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1516895-53-6
Synonyms: SEP 0372814，SEP0372814
SMILES: CC1=CN=C(C2=NC(=NN12)[C@@H]3C[C@H]3C4=C(N5C=CC6=C(C5=N4)C=CC=N6)C)C
Formula: C21H21N7
M.Wt: 371.19
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: SEP-0372814 is a potent PDE10 inhibitor.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC9847 Vesnarinone(OPC8212) Vesnarinone is a quinolinone derivative, and its pharmacodynamic effects include inhibition of phosphodiesterase III (PDE3) activity, increases in calcium flux and decreases in potassium flux.
DC7945 TAK-063 TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs.
DC9779 Sildenafil citrate Sildenafil citrate, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.
DC8048 SEP-0372814 SEP-0372814 is a potent PDE10 inhibitor.
DC4146 Roflumilast Roflumilast (Daxas) is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM.
DC7247 PF-8380 PF-8380 is a potent and specofic autotaxin inhibitor with an IC50 value of 2.8 nM.
DC7201 PF-2545920(MP-10) PF-2545920 a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM.
DC11367 PF-04447943 PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis.
DC9577 Olprinone (Hydrochloride) Olprinone Hcl(Loprinone Hcl) is a selective phosphodiesterase 3 (PDE3) inhibitor.
DC7676 IBMX(NSC165960; SC2964) IBMX(NSC165960; SC2964) is a competitive nonselective PDEs inhibitor with IC50 of 2-50 uM but does not inhibit PDE8 or PDE9; nonselective adenosine receptor antagonist.
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