| DC9847 |
Vesnarinone(OPC8212)
|
Vesnarinone is a quinolinone derivative, and its pharmacodynamic effects include inhibition of phosphodiesterase III (PDE3) activity, increases in calcium flux and decreases in potassium flux. |
| DC7945 |
TAK-063
|
TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs. |
| DC9779 |
Sildenafil citrate
|
Sildenafil citrate, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction. |
| DC8048 |
SEP-0372814
|
SEP-0372814 is a potent PDE10 inhibitor. |
| DC4146 |
Roflumilast
|
Roflumilast (Daxas) is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM. |
| DC7247 |
PF-8380
|
PF-8380 is a potent and specofic autotaxin inhibitor with an IC50 value of 2.8 nM. |
| DC7201 |
PF-2545920(MP-10)
|
PF-2545920 a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM. |
| DC11367 |
PF-04447943
|
PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis. |
| DC9577 |
Olprinone (Hydrochloride)
|
Olprinone Hcl(Loprinone Hcl) is a selective phosphodiesterase 3 (PDE3) inhibitor. |
| DC7676 |
IBMX(NSC165960; SC2964)
|
IBMX(NSC165960; SC2964) is a competitive nonselective PDEs inhibitor with IC50 of 2-50 uM but does not inhibit PDE8 or PDE9; nonselective adenosine receptor antagonist. |
