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SKF38393 HCl

  Cat. No.:  DC8859   Featured
Chemical Structure
62717-42-4
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More than 5000 active chemicals with high quality for research!
Field of application
SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 62717-42-4
SMILES: Cl.C1(C2C3C=C(O)C(O)=CC=3CCNC2)C=CC=CC=1
Formula: C16H17NO2.HCl
M.Wt: 291.77
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: SKF 38393 hydrochloride is a D1 agonist with IC50 of 110 nM.SKF 38393 hydrochloride is a benzazepine selective agonist of the D1DR (dopamine D1 receptor). Agonism of the D1DR by SKF 38393 is correlated to induced desynchronization of electroencephalographic activity in rats. SKF 38393 is also reported to demonstrate agonism of the serotonin SR-2C (5-HT1C receptor). SKF 38393 HCl is an activator of D5DR. SKF 38393 is a synthetic compound of the benzazepine chemical class which acts as a selective D1/D5 receptor partial agonist. It has stimulant and anorectic effects. SKF-38393 enhances the frequency of mEPSCs in a concentration-dependent manner. SKF-38393 enhances the frequency of mEPSCs in a concentration-dependent manner. [2]
Target: IC50 value: 110 nM [1] Target: D1 agonist
References: [1]. Altar CA, et al. Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction auto radiography. J Neurosci. 1987 Jan;7(1):213-222. [2]. Bouron A, et al. The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus. Neuroscience. 1999;94(4):1063-1070. [3]. Chocyk A, et al. Dopamine D1-like receptors agonist SKF 38393 increases cFOS expression in the paraventricular nucleus of the hypothalamus--impact of acute and chronic cocaine. J Physiol Pharmacol. 2008 Sep;59(3):425-440.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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