SN-38(NK-012)

Cas No.:	86639-52-3
Chemical Name:	SN-38
Synonyms:	7-Ethyl-10-hydroxycamptothecin;CAMPTOTHECIN, 10-HYDROXY-;CAMPTOTHECIN, 10-HYDROXY-, CAMPTOTHECA ACUMINATA;HCPT;HYDROXYCAMPTOTHECIN;HYDROXYCAMPTOTHECIN, 10-;SN38;1H-Pyrano3,4:6,7indolizino1,2-bquinoline-3,14(4H,12H)-dione, 4-ethyl-4,10-dihydroxy-;7-Ethyl-10-hydroxy-camptothecine;4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;7-Ethyl-10-Hydroxy-Camptothecin;7-Ethyl-10-hydroxycamptothecin(SN38);7-Ethyl-10-Hydroxycamptothecin(SN-38);7-Ethyl-10-hydroxycamptothecine;SN-38;(S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;1-Ethoxy-2-propanol;Irinotecan Related CoMpound B;NK012;NK-012;(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione;SN 38 lactone;SN 38;10-Hydroxy-7-ethylcamptothecin;NK 012;NSC673596;0H43101T0J;7–Ethyl–10–hydroxycamptothecin;UQ0491000;(+)-7-ETHYL-10-HYDROXYCAMPTOTHECIN;(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione;10.1158/0008-5472.CAN-03-3344;1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4,7-diethyl-4,10-dihydroxy-;7???ethyl???10???hydroxycamptothecin;7-Ethyl-10- hydroxycamptothecin;7-Ethyl-10-hydroxy camptothecin;7-ethyl-10-hydroxy camptothecine;7-Ethyl-10-hydroxy-20(S)-camptothecin;7-Ethyl-10-hydroxy-20-(S)-camptothecine;7-Ethyl-10-hydroxycamptothecin |;7-Ethyl-10-hydroxycamptothecin|SN 38;7-ETHYL-10-HYDROXY-CAPTOTHECIN;BR-36613;Captothecin, 7-ethyl-10-hydroxy-;CHEBI:8988;EHC;https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:8988;LE-SN38;SN 38; SN38;NK-012;NK012;NK 012;SN-38-d3;UNII:0H43101T0J;UNII-0H43101T0J;(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (ACI);1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (S)- (ZCI);(19S)-10,19-Diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione;(S)-SN 38;SN 38 (pharmaceutical);7-Ethyl-10-hydroxycamptothecin (SN-38)
SMILES:	C(C1C2C=C(C=CC=2N=C2C3=CC4[C@@](C(OCC=4C(=O)N3CC=12)=O)(O)CC)O)C
Formula:	C22H20N2O5
M.Wt:	392.404605865479
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:	SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively.
In Vivo:	SN-38, the active and toxic metabolite of the anticancer prodrug Irinotecan. At 30 minutes after administration, Irinotecan plasma concentrations in Slco1a/1b(−/−) mice are 1.9-fold higher than in the wild-type mice (1.89 vs. 1.01 μM, respectively), whereas SN-38 plasma concentrations of Slco1a/1b(−/−) mice are 8-fold higher compare with wild-type mice (0.4 μg/mL vs. 0.05 μg/mL, respectively). Overall plasma exposure [AUC(5-240)] of Irinotecan is 1.7-fold higher in Oatp1a/1b knockout mice versus wild-type mice (209.8±6.7 vs. 120.9±4.4 μM/min; P<0.01), and 2.9-fold higher for SN-38 (50±2.9 vs. 12±2 μM/min; P<0.001)[3].
In Vitro:	The IC50 values for LoVo, HCT116, and HT29 cell lines is 20 nM, 50 nM, 130 nM, respectively. In all three SN-38 resistant cell lines Top1 activity is maintained in the presence of high concentrations of SN-38[2].