Cas No.: | 2319790-02-6 |
Chemical Name: | SSD114 hydrochloride |
Synonyms: | SSD-114,SSD 114 |
SMILES: | FC(F)(F)C1C=CC(C2N=C(NC3CCCCC3)N=C(OC)C=2)=CC=1.[H]Cl |
Formula: | C18H21ClF3N3O |
M.Wt: | 387.83 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | SSD114 is a novel GABAB positive allosteric modulator. SSD114 potentiates the GABA inhibition of adenylyl-cyclase mediated by GABAB receptors. SSD114 is also effective in vivo potentiating baclofen-induced sedation/hypnosis in mice, with no effect when tested alone. These findings indicate that SSD114, a molecule with a different chemical structure compared to known GABAB PAMs, is a novel GABAB PAM with potential usefulness in the GABAB-receptor research field. |