| Cas No.: | 182485-36-5 |
| Chemical Name: | Phosphinic acid,P-methyl-P-(1,2,3,6-tetrahydro-4-pyridinyl)- |
| Synonyms: | Phosphinic acid,P-methyl-P-(1,2,3,6-tetrahydro-4-pyridinyl)-;(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate;TPMPA;(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinicacid;TPMPA hydrate;tpmpa hydrate;MFUKVPOVVKKLRQ-UHFFFAOYSA-N;(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID;(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID HYDRATE |
| SMILES: | CP(C1=CCNCC1)(=O)O |
| Formula: | C6H12NO2P |
| M.Wt: | 161.138742446899 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells[1][2][3]. |
| Target: | KB: 2.1 μM (GABAC) |
| In Vitro: | TPMPA antagonizes the GABA currents of ρ1 receptors (IC50 = 1.6 μM) and those of the chimeric ρ1/α1 receptors with approximately the same potency (IC50 = 1.3 μM)[1]. TPMPA shows weak activity against rho-1 and rho-2 receptors, with the KB values of 2.0 and 15.6 μM, respectively[2] |
| References: | [1]. Martínez-Torres A, et al. GABArho 1/GABAAalpha 1 receptor chimeras to study receptor desensitization. Proc Natl Acad Sci U S A. 2000;97(7):3562-3566. [2]. Graham A. R. Johnston, et al. Neurologically-active compounds. WO1998058939A1 [3]. Johnston GA. GABAc receptors: relatively simple transmitter -gated ion channels?. Trends Pharmacol Sci. 1996;17(9):319-323. |
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| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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| 2018-0101 |
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