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THPP-1

  Cat. No.:  DC28378   Featured
Chemical Structure
1257051-63-0
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More than 5000 active chemicals with high quality for research!
Field of application
THPP-1, a SGC chemical probe, is a potent and orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor, with Ki values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokinetic properties in preclinical species.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1257051-63-0
Chemical Name: THPP-1
Synonyms: THPP-1;[2-(6-chloropyridin-3-yl)-4-(2-methoxyethoxy)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-imidazo[1,5-a]pyridin-1-ylmethanone;BDBM50401294;US8492392, 64;CID 49821991;PDE10A,SIMA,object,THPP 1,recognition,Phosphodiesterase (PDE),Inhibitor,inhibit,novel,THPP-1,THPP1;Methanone, [2-(6-chloro-3-pyridinyl)-7,8-dihydro-4-(2-methoxyethoxy)pyrido[4,3-d]pyrimidin-6(5H)-yl]imidazo[1,5-a]pyridin-1-yl-;CHEMBL2204538;DA-78439;G17214;(2-(6-Chloropyridin-3-yl)-4-(2-methoxyethoxy)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)(imidazo[1,5-a]pyridin-1-yl)methanone;AKOS040759431;CS-0066613;MS-28568;EX-A4562;2-chloro-5-(6-{imidazo[1,5-a]pyridine-1-carbonyl}-4-(2-methoxyethoxy)-5H,7H,8H-pyrido[4,3-d]pyrimidin-2-yl)pyridine;1257051-63-0;SCHEMBL415756;HY-117604
SMILES: ClC1=CC=C(C=N1)C1=NC(=C2C(CCN(C(C3=C4C=CC=CN4C=N3)=O)C2)=N1)OCCOC
Formula: C23H21ClN6O3
M.Wt: 464.9
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DC28378 THPP-1 THPP-1, a SGC chemical probe, is a potent and orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor, with Ki values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokinetic properties in preclinical species.
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