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MBCQ

  Cat. No.:  DC42521   Featured
Chemical Structure
150450-53-6
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Field of application
MBCQ is a potent and selective the type V phosphodiesterase (PDE V; PDE5) inhibitor with an IC50 of 19 nM. MBCQ has IC50s >100 µM for PDE1, PDE2, PDE3, and PDE4, respectively. MBCQ dilates coronary arteries via potent and specific inhibition of cGMP-PDE.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 150450-53-6
Chemical Name: MBCQ
Synonyms: N-(1,3-benzodioxol-5-ylmethyl)-6-chloroquinazolin-4-amine;UPCMLD-DP008;SureCN2458882;4-[[3,4-(methylenedioxy)benzyl]amino]-6-chloroquinazoline;Bio2_000664;4-(3,4-methylenedioxybenzyl)amino-6-chloroquinazoline;AC1O7M1X;KBioGR_000184;ACMC-20ejrz;BSPBio_001464;4-Quinazolinamine, N-(1,3-benzodioxol-5-ylmethyl)-6-chloro-;KBioSS_000184;4-[[3,4-(methyenedioxy)benzyl]amino]-6-chloroquinazole;4-((3,4-Methylenedioxybenzyl)amino)-6-chloroquinazoline;UPCMLD-DP008;;4-((3,4-Methylenedioxybenzyl)amino)-6-chloroquinazoline;MBCQ;N-(1,3-BENZODIOXOL-5-YLMETHYL)-6-CHLORO-4-QUINAZOLINAMINE;4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE
SMILES: O1C2C=CC(CNC3C4C(=CC=C(Cl)C=4)N=CN=3)=CC=2OC1
Formula: C16H12N3O2Cl
M.Wt: 313.73838
Purity: >98%
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
MSDS
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MSDS_26149_DC42521_150450-53-6
COA
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Cat. No. Product name Field of application
DC73764 CRD733 CRD733 (ASP4901) is a potent, selective cGMP-specific PDE9 (phosphodiesterase 9) inhibitor.
DC73763 CC-11050 Dovramilast (CC-11050) is a potent and orally active phosphodiesterase 4 (PDE4) inhibitor, CC-11050 is a promising candidate for host directed therapy of patients with pulmonary TB.
DC71683 Lodenafil Lodenafil (Hydroxyhomosildenafil) is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED).
DC70239 BAY 2666605 BAY2666605 is a potent, small molecule PDE3A-SLFN12 complex inducer with EC50 of 7 nM.BAY2666605 triggers the formation of a complex of two proteins called SLFN12 and PDE3A. This complex drive cancer cells into cell death by a mechanism called apoptosis.
DC48226 ONO-8430506 ONO-8430506 is an orally bioavailable and potent autotaxin (ATX)/ENPP2 inhibitor with the IC90 of 100 nM for ATX activity in mouse plasma.
DC42521 MBCQ MBCQ is a potent and selective the type V phosphodiesterase (PDE V; PDE5) inhibitor with an IC50 of 19 nM. MBCQ has IC50s >100 µM for PDE1, PDE2, PDE3, and PDE4, respectively. MBCQ dilates coronary arteries via potent and specific inhibition of cGMP-PDE.
DC40977 DSR-141562 DSR-141562 is a novel, orally active, and selective brain-penetrant phosphodiesterase 1 (PDE1) inhibitor. DSR-141562 shows preferential selectivity for human PDE1B with an IC50 of 43.9 nM, and the IC50 values for human PDE1A and 1C are 97.6 and 431.8 nM, respectively. DSR-141562 can be used for the study of positive symptoms, negative symptoms and cognitive impairments associated with schizophrenia.
DC40378 MR-L2 MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC50 of 1.2 μM.
DC28378 THPP-1 THPP-1, a SGC chemical probe, is a potent and orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor, with Ki values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokinetic properties in preclinical species.
DC28354 (E/Z)HA-155 (E/Z)HA-155 is a potent and selective autotaxin (ATX) inhibitor with an IC50 of 5.7 nM.
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