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TH 287

  Cat. No.:  DC7725   Featured
Chemical Structure
1609960-30-6
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More than 5000 active chemicals with high quality for research!
Field of application
TH 287 is a first-in-class MTH1 inhibitor (IC50 value 5.0 nM) that selectively and effectively kills U2OS and other cancer cell lines, with considerably less toxicity towards several primary or immortalized cells.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1609960-30-6
Synonyms: TH287,TH-287
SMILES: CNC1=NC(=NC(=C1)C2=C(C(=CC=C2)Cl)Cl)N
Formula: C11H10Cl2N4
M.Wt: 269.13
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: TH287 is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.TH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies.
Target: IC50 value: 0.8 nM [1] Target: MTH1 inhibitor
References: [1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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