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TSHR antagonist S37b

  Cat. No.:  DC40415  
Chemical Structure
2143452-22-4
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Field of application
TSHR antagonist S37b is an enantiomer of TSHR antagonist S37a, shows only a minor effect for TSHR inhibition. TSHR antagonist S37b can be used for the research of thyroid function.
Cas No.: 2143452-22-4
Chemical Name: TSHR antagonist S37b
Synonyms: TSHR antagonist S37b;5,9-Methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione, 3,4a,5,5a,8a,9,9a,10-octahydro-7,10-diphenyl-, (4aR,5R,5aS,8aS,9S,9aR,10S)-
SMILES: C1(=O)[C@]2([H])[C@@]([H])([C@@]3([H])C[C@]2([H])[C@]2([H])[C@@H](C4=CC=CC=C4)C4SC(=O)NC=4S[C@]32[H])C(=O)N1C1=CC=CC=C1
Formula: C25H20N2O3S2
M.Wt: 460.57
Purity: >98%
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC73510 Org 274179-0 Org 274179-0 is a highly potent, allosteric antagonist of the thyroid-stimulating hormone receptor (TSH receptor), inhibits bTSH-, hTSH- and M22-mediated CRE-luciferase transactivation in the CHO cell line.
DC40415 TSHR antagonist S37b TSHR antagonist S37b is an enantiomer of TSHR antagonist S37a, shows only a minor effect for TSHR inhibition. TSHR antagonist S37b can be used for the research of thyroid function.
DC73511 SYD5115 (SYD-5115, SYD 5115) SYD5115 (SYD-5115) is a potent, selective and orally bioavailable thyrotropin receptor (TSH-R) antagonist with IC50 of 48 and 62 nM for rTSHR and hTSHR, respectively.
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