TT-10|TT10|cardiomyocyte proliferation

Cas No.:	2230640-94-3
Chemical Name:	(2-(Allylamino)-4-aminothiazol-5-yl)(5-fluorothiophen-2-yl)methanone
Synonyms:	(2-(Allylamino)-4-aminothiazol-5-yl)(5-fluorothiophen-2-yl)methanone;TT10
SMILES:	S1C(=NC(=C1C(C1=CC=C(F)S1)=O)N)NCC=C
Formula:	C₁₁H₁₀FN₃Os₂
M.Wt:	283.345002651215
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

TT-10 is a novel multifaceted fluorinated compound with promising features of CM proliferative, antioxidant, and antiapoptotic activities in vitro. The intraperitoneal injection of TT-10 in mice after MI promoted CM proliferation and reduced infarct size and fibrosis, which resulted in amelioration of cardiac dysfunction. Stimulating endogenous CM proliferation and/or protection with TT-10 treatment may be a desirable strategy to complement current therapies for acute MI.TT-10 promoted cardiomyocyte proliferation and simultaneously exerted antioxidant and antiapoptotic effects in vitro. TT-10 treatment in mice ameliorated myocardial infarction–induced cardiac dysfunction at least in part via enhancing clonal expansion of existing cardiomyocytes with nuclear YES-associated protein expression. Stimulating cardiomyocyte proliferation and/or protection with TT-10 might complement current therapies for myocardial infarction.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC5886	Verteporfin (Visudyne)	Verteporfin(CL 318952; Visudyne), a benzoporphyrin derivative monoacid ring A, is a photosensitising drug for photodynamic therapy (PDT) activated by low-intensity, nonheat-generating light of 689nm wavelength.
DC11444	TT-10	TT-10 is a novel multifaceted fluorinated compound with promising features of CM proliferative, antioxidant, and antiapoptotic activities in vitro.