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| Cas No.: | 183204-72-0 |
| Chemical Name: | Tipiracil HCl |
| Synonyms: | 5-CIMU; TAS-1-462, MA-1; Tipiracil HCl, TPI; TAS-102; Lonsurf. |
| SMILES: | C1CC(=N)N(C1)CC2=C(C(=O)NC(=O)N2)Cl.Cl |
| Formula: | C9H12Cl2N4O2 |
| M.Wt: | 279.123 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research. |
| In Vitro: | Tipiracil has antiangiogenic effect, and inhibits proliferation of endothelial cells[1]. Tipiracil is a potent inhibitor of thymidine phosphorylase, which is the enzyme that degrades FTD[2]. |
| References: | [1]. Peters GJ, et al. TAS-102: more than an antimetabolite. Lancet Oncol. 2012 Dec;13(12):e518-9. [2]. Yoshino T, et al. TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol. 2012 Oct;13(10):993-1001. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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