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Tipiracil hydrochloride

  Cat. No.:  DC8758   Featured
Chemical Structure
183204-72-0
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More than 5000 active chemicals with high quality for research!
Field of application
Tipiralacil(TPI) is a thymidine phosphorylase inhibitor (TPI). Tipiracil is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 183204-72-0
Chemical Name: 5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione hydrochloride
Synonyms: 5-CIMU; TAS-1-462, MA-1; Tipiracil HCl, TPI; TAS-102; Lonsurf.
SMILES: C1CC(=N)N(C1)CC2=C(C(=O)NC(=O)N2)Cl.Cl
Formula: C9H12Cl2N4O2
M.Wt: 279.12318
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.
In Vitro: Tipiracil has antiangiogenic effect, and inhibits proliferation of endothelial cells[1]. Tipiracil is a potent inhibitor of thymidine phosphorylase, which is the enzyme that degrades FTD[2].
References: [1]. Peters GJ, et al. TAS-102: more than an antimetabolite. Lancet Oncol. 2012 Dec;13(12):e518-9. [2]. Yoshino T, et al. TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol. 2012 Oct;13(10):993-1001.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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DC8758 Tipiracil hydrochloride Tipiralacil(TPI) is a thymidine phosphorylase inhibitor (TPI). Tipiracil is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials.
DC8940 Raltitrexed Raltitrexed(ZD1694), an inhibitor of thymidylate synthase, is an antimetabolite drug used in cancer chemotherapy.
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