ZINC00881524|cas 557782-81-7

Cas No.:	557782-81-7
Chemical Name:	ZINC00881524
Synonyms:	N-(4,5-dihydronaphtho[1,2-d]thiazol-2-yl)-2-(3,4-dimethoxyphenyl)acetamide;ZINC00881524;BCP25184;s8448;N-(4,5-dihydrobenzo[e][1,3]benzothiazol-2-yl)-2-(3,4-dimethoxyphenyl)acetamide;BS-17128;DA-79108;Z29097069;C21H20N2O3S;HY-101244;ZINC-00881524;AC-36854;A935148;CCG-268409;2-(3,4-DIMETHOXYPHENYL)-N-{4H,5H-NAPHTHO[1,2-D][1,3]THIAZOL-2-YL}ACETAMIDE;557782-81-7;953928-62-6;ZINC00881524 (ROCK inhibitor);CS-6520;AKOS001072293;EX-A1504
SMILES:	S1C(N([H])C(C([H])([H])C2C([H])=C([H])C(=C(C=2[H])OC([H])([H])[H])OC([H])([H])[H])=O)=NC2C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])C1=2
Formula:	C₂₁H₂₀N₂O₃S
M.Wt:	380.4601
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

COA

Cat. No.	Product name	Field of application
DC72592	Zelasudil	Zelasudil is a Rho-associated coiled-coil kinase (ROCK) inhibitor with a specific binding affinity for ROCK2, a key enzyme in the Rho/ROCK signaling pathway. This pathway plays a critical role in regulating cellular processes such as cytoskeletal organization, cell motility, smooth muscle contraction, and gene expression. By selectively inhibiting ROCK2, Zelasudil modulates these processes, offering therapeutic potential for a variety of diseases characterized by fibrosis, inflammation, and vascular dysfunction, including pulmonary fibrosis, glaucoma, and cardiovascular diseases.
DC45762	Y-27632	Y-27632 is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.
DC10167	ZINC00881524	ZINC00881524 is a ROCK inhibitor.
DC8567	3-(4-Pyridyl)	3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay