Zelasudil
Cat. No.: DC72592
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Chemical Structure
2365193-22-0
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Field of application
Zelasudil is a Rho-associated coiled-coil kinase (ROCK) inhibitor with a specific binding affinity for ROCK2, a key enzyme in the Rho/ROCK signaling pathway. This pathway plays a critical role in regulating cellular processes such as cytoskeletal organization, cell motility, smooth muscle contraction, and gene expression. By selectively inhibiting ROCK2, Zelasudil modulates these processes, offering therapeutic potential for a variety of diseases characterized by fibrosis, inflammation, and vascular dysfunction, including pulmonary fibrosis, glaucoma, and cardiovascular diseases.
| Cas No.: |
2365193-22-0 |
| Chemical Name: |
Zelasudil |
| SMILES: |
O=C(C1=CC=C(C2=NN(C)C(NC3=CC=C4NN=CC4=C3C5CC5)=N2)C=C1)NCC(F)F |
| Formula: |
C22H21F2N7O |
| M.Wt: |
437.45 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Publication: |
[1]. Lee E, et al. Selective ROCK2 inhibition for treatment of edema and associated conditions: World Intellectual Property Organization, WO2022169946. 2022-08-11.
[2]. WHO Drug Information-World Health Organization (WHO). |
| Description: |
Zelasudil is a Rho-associated (ROCK) kinase inhibitor. Zelasudil has a ROCK2 binding affinity. |
| References: |
[1]. Lee E, et al. Selective ROCK2 inhibition for treatment of edema and associated conditions: World Intellectual Property Organization, WO2022169946. 2022-08-11.
[2]. WHO Drug Information-World Health Organization (WHO). |
MSDS
| TITLE |
DOWNLOAD |
| MSDS_37115_DC72592_2365193-22-0 |
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COA
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