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α-Conotoxin MII

  Cat. No.:  DC41803   Featured
Chemical Structure
175735-93-0
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Field of application
α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuronal nicotinic receptors. Displays > 200-fold selectivity for α3β2 over α2β2, α4β2 and α3β4.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 175735-93-0
Chemical Name: alpha-conotoxin MII
Synonyms: alpha-conotoxin MII;alpha-MII;MII;α-conotoxin MII;α-CTxMII
SMILES: N12C(=O)C(C(C(=O)N([H])[H])([H])[H])([H])N([H])C(=O)C(C(O[H])([H])[H])([H])N([H])C(=O)C3(C(SSC(C(N(C(C(N(C(C(N(C(C(N(C(C(N(C(C(N(C(C(N(C(C(N(C(=O)C(C(SSC(C(C(N3[H])=O)(N(C(C(N([H])[H])([H])[H])=O)[H])[H])([H])[H])([H])[H])([H])N([H])C(=O)C(C(C([H])([H])[H])(C([H])([H])[H])[H])([H])N([H])C(=O)C1(C(C(C2([H])[H])([H])[H])([H])[H])[H])[H])(C(c1nc([H])[n]([H])c1[H])([H])[H])[H])=O)[H])(C(C(C([H])([H])[H])(C([H])([H])[H])[H])([H])[H])[H])=O)[H])(C(C(C(O[H])=O)([H])[H])([H])[H])[H])=O)[H])(C(c1nc([H])[n]([H])c1[H])([H])[H])[H])=O)[H])(C(O[H])([H])[H])[H])=O)[H])(C(C(=O)N([H])[H])([H])[H])[H])=O)[H])(C(C(C([H])([H])[H])(C([H])([H])[H])[H])([H])[H])[H])=O)[H])(C(=O)N([H])[H])[H])([H])[H])([H])[H])[H]
Formula: C67H103N23O22S4
M.Wt: 1710.94
Purity: >98%
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
Description: α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuronal nicotinic receptors. Displays > 200-fold selectivity for α3β2 over α2β2, α4β2 and α3β4.
Target: IC50: 0.5 nM (α3β2)[1].
In Vitro: α-Conotoxin MII (0.5-3.5 nM) blocks ACh responses in oocytes expressing α3β2 nicotinic acetylcholine receptors[1][2].
References: [1]. G E Cartier, et al. A New Alpha-Conotoxin Which Targets alpha3beta2 Nicotinic Acetylcholine Receptors. J Biol Chem. 1996 Mar 29;271(13):7522-8. [2]. S C Harvey, et al. Determinants of Specificity for Alpha-Conotoxin MII on alpha3beta2 Neuronal Nicotinic Receptors. Mol Pharmacol. 1997 Feb;51(2):336-42. [3]. J M McIntosh, et al. Conus Peptides: Novel Probes for Nicotinic Acetylcholine Receptor Structure and Function. Eur J Pharmacol. 2000 Mar 30;393(1-3):205-8.
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Cat. No. Product name Field of application
DC41803 α-Conotoxin MII α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuronal nicotinic receptors. Displays > 200-fold selectivity for α3β2 over α2β2, α4β2 and α3β4.
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