Avatrombopag maleate
Cat. No.: DC71008
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Chemical Structure
677007-74-8
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Field of application
Avatrombopag maleate (AKR-501) is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag maleate mimics the biological activities of TPO. Avatrombopag maleate increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag maleate is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A.
| Cas No.: |
677007-74-8 |
| Chemical Name: |
Avatrombopag maleate |
| Synonyms: |
Avatrombopag maleate;E5501 MALEATE;GDW7M2P1IS;Avatrombopag Meleate;4-Piperidinecarboxylic acid, 1-(3-chloro-5-(((4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1- piperazinyl)-2-thiazolyl)amino)carbonyl)-2-pyridinyl)-, (2Z)-2-butenedioate (1:1);Avatrombopag maleate [USAN];Doptelet (TN);Avatrombopag maleate (JAN/USAN);D10307;Q27279052;1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyc |
| SMILES: |
ClC1C([H])=C(C([H])=NC=1N1C([H])([H])C([H])([H])C([H])(C(=O)O[H])C([H])([H])C1([H])[H])C(N([H])C1=NC(C2=C([H])C(=C([H])S2)Cl)=C(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S1)=O.O([H])C(/C(/[H])=C(/[H])\C(=O)O[H])=O |
| Formula: |
C33H38Cl2N6O7S2 |
| M.Wt: |
765.7268 |
| Purity: |
98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
MSDS
| TITLE |
DOWNLOAD |
| MSDS_35234_DC71008_677007-74-8 |
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COA
| LOT NO. |
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