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BAY-405

Cat. No.: DC74333 Featured

Chemical Structure

2442532-66-1

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Field of application

BAY-405 is a potent and selective MAP4K1 inhibitor with IC50 of 6 nM. BAY-405 potentiates in vitro and in vivo antitumor T-cell reactivity which overcomes the suppression by TGFβ and PGE2.

Chemicals Properties Biological activity COA & MSDS Related products Datasheet

Cas No.:	2442532-66-1
Chemical Name:	BAY-405
Formula:	C₂₅H₂₃F₅N₄O₃
M.Wt:	522.48
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

Cat. No.	Product name	Field of application
DC74333	BAY-405	BAY-405 is a potent and selective MAP4K1 inhibitor with IC50 of 6 nM. BAY-405 potentiates in vitro and in vivo antitumor T-cell reactivity which overcomes the suppression by TGFβ and PGE2.
DC72741	BGB 15025	BGB-15025 is a potent and selective HPK1 inhibitor. It is used in the treatment of various cancers.
DC46921	HPK1-IN-7	HPK1-IN-7 is a potent, orally active HPK1 (hematopoietic progenitor kinase 1, MAP4K1) inhibitor (IC50=2.6 nM) with excellent family and kinome selectivity. HPK1-IN-7 shows selectivity against IRAK4 (59 nM) and GLK (140 nM). HPK1-IN-7 shows robust efficacy against MC38 syngeneic tumor model in combination with anti-PD1.

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