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| Cas No.: | 2766481-17-6 |
| Chemical Name: | Benzamide, 4-[5-amino-6-[[1-(1-methyl-4-piperidinyl)-1H-pyrazol-4-yl]oxy]-2-pyrazinyl]-N-[2-[(3R)-3-fluoro-1-pyrrolidinyl]ethyl]-2,6-dimethyl- |
| Synonyms: | Benzamide, 4-[5-amino-6-[[1-(1-methyl-4-piperidinyl)-1H-pyrazol-4-yl]oxy]-2-pyrazinyl]-N-[2-[(3R)-3-fluoro-1-pyrrolidinyl]ethyl]-2,6-dimethyl-;BGB-15025 |
| SMILES: | C1CN(C)CCC1N1C=C(OC2N=C(C3=CC(C)=C(C(NCCN4CC[C@@H](F)C4)=O)C(C)=C3)C=NC=2N)C=N1 |
| Formula: | C28H37FN8O2 |
| M.Wt: | 536.64 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | BGB-15025 is a potent and selective HPK1 inhibitor. It is used in the treatment of various cancers. |
| Target: | HPK1 |
| In Vitro: | HPK1-IN-32 (Example A34, 0-2 μM, 2 h) inhibits pSLP76 activity in Jurkat cells with an IC50 of 65 nM [1]. |
| References: | [1]. Sanjia XU, et al. 3-[(1h-pyrazol-4-yl)oxy]pyrazin-2-amine compounds as hpk1 inhibitor and use thereof. Patent. WO2022068848. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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