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Home > Inhibitors & Agonists > Tyrosine Kinase > c-Kit

Bezuclastinib

  Cat. No.:  DC48359   Featured
Chemical Structure
1616385-51-3
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More than 5000 active chemicals with high quality for research!
Field of application
Bezuclastinib (PLX 9486; CGT9486) is a potent inhibitor of c-kit and c-kit D816V (0.0001
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1616385-51-3
Chemical Name: 4,5-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-3-carboxamide
Synonyms: 4,5-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-3-carboxamide;Bezuclastinib;3,4-Dimethyl-N-(2-phenyl-1H-pyrrolo(2,3-b)pyridin-5-yl)-1H-pyrazole-5-carboxamide;3,4-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-5-carboxamide;2ROQ545LAG;CGT9486;PLX 9486 [WHO-DD];BDBM392363;3,4-dimethyl-N-(2-phenyl-1H- pyrrolo[2,3-b]pyridin-5-yl)-1H- pyrazole-5-carboxamide
SMILES: O=C(C1C(C([H])([H])[H])=C(C([H])([H])[H])N([H])N=1)N([H])C1=C([H])N=C2C(=C1[H])C([H])=C(C1C([H])=C([H])C([H])=C([H])C=1[H])N2[H]
Formula: C19H17N5O
M.Wt: 331.3712
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_32250_DC48359_1616385-51-3
COA
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Cat. No. Product name Field of application
DC72747 Elenestinib Elenestinib (BLU-263) is a potent and orally active tyrosine kinase inhibitor. Elenestinib has the potential for the research of systemic mastocytosis (SM).
DC48359 Bezuclastinib Bezuclastinib (PLX 9486; CGT9486) is a potent inhibitor of c-kit and c-kit D816V (0.0001
DC44837 M4205 M4205 is a c-KIT inhibitor, with an IC50 of 10 nM for c-KIT V654A. M4205 has high activity on c-KIT mutations in exon 11, 13, 17.
DC7219 OSI 930 OSI-930 is a potent inhibitor of Kit, KDR and CSF-1R with IC50 of 80 nM, 9 nM and 15 nM, respectively; also potent to Flt-1, c-Raf and Lck and low activity against PDGFRα/β, Flt-3 and Abl.
DC10082 ISCK03 ISCK03 is a cell-permeable inhibitor of SCF-mediated c-kit activation, completely blocking phosphorylation of c-kit in human melanoma cells at a concentration between 1 and 5 µM.
DC9585 c-Kit-IN-1(DCC-2618) DCC-2618 is a small molecule inhibitor of c-Kit and PDGFR with IC50s of 6 nM/30 nM/13 nM for c-Kit/PDGFRα/PDGFRβ respectively.
DC10530 BLU-285 (Avapritinib) BLU-285 is a potent and selective exon 17 mutant KIT kinase inhibitor with IC50 of 0.27 nM for KIT D816V.
DC7324 Amuvatinib (MP-470) Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively.
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