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BFL-1 inhibitor 4E14

  Cat. No.:  DC70246   Featured
Chemical Structure
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Field of application
BFL-1 inhibitor 4E14 (4E14) is a potent, selective, covalent BFL-1 inhibitor that disrupt BH3-binding activity with IC50 of 1.3 uM, targets a unique C55 residue in the BFL-1 groove.4E14 blocks BFL-1 suppression of BAX-mediated mitochondrial apoptosis.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.:
Chemical Name: BFL-1 inhibitor 4E14
Formula: C19H28N4O2S2
M.Wt: 408.579
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Edward P Harvey, et al. Cell Chem Biol. 2020 Jun 18;27(6):647-656.e6.
Description: BFL-1 inhibitor 4E14 (4E14) is a potent, selective, covalent BFL-1 inhibitor that disrupt BH3-binding activity with IC50 of 1.3 uM, targets a unique C55 residue in the BFL-1 groove.4E14 blocks BFL-1 suppression of BAX-mediated mitochondrial apoptosis.
References: 1. Edward P Harvey, et al. Cell Chem Biol. 2020 Jun 18;27(6):647-656.e6.
MSDS
COA
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2018-0101
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