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cardamonin

  Cat. No.:  DC6502   Featured
Chemical Structure
19309-14-9
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More than 5000 active chemicals with high quality for research!
Field of application
Cardamonin, isolated from the fruits of Alpinia species, is a chalconoid with anti-inflammatory and anti-tumor activity.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 19309-14-9
SMILES: O=C(C1=C(OC)C=C(O)C=C1O)/C=C/C2=CC=CC=C2.[E]
Formula: C16H14O4
M.Wt: 270.28
Sotrage: 4°C for 1 year, -20°C for more than 2 years
Description: Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM
In Vivo: Cardamonin (3-30 mg/kg, orally administered) significantly inhibits PBQ-induced writhing. CDN also produces a significant, dose-dependent increase in the withdrawal response latencies in carrageenan-induced hyperalgesia[2].
In Vitro: Cardamonin selectively blocksTRPA1 activation (IC50=454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. Cardamonin does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction[1]. Cardamonin suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells[2].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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