Cedirogant|CAS 2055496-11-0|DC Chemicals

Cas No.:	2055496-11-0
Chemical Name:	Cedirogant
Synonyms:	Cedirogant;X6466M4LVP;Cedirogant [INN];Cedirogant [USAN];BDBM292795;US10106501, Example EI-5;US10106501, Example EI-6;WHO 11460;(1-(2,4-Dichloro-3-((7-chloro-5-(trifluoromethyl)-1hindol-1-yl)methyl)benzoyl)piperidin-4-yl)acetic acid;4-Piperidineacetic acid, 1-(2,4-dichloro-3-((7-chloro-5-(trifluoromethyl)-1H-indol-1-yl)methyl)benzoyl)-
SMILES:	ClC1C(=C(C=CC=1C(N1CCC(CC(=O)O)CC1)=O)Cl)CN1C=CC2C=C(C(F)(F)F)C=C(C1=2)Cl
Formula:	C₂₄H₂₀Cl₃F₃N₂O₃
M.Wt:	547.781414031982
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

COA

Cat. No.	Product name	Field of application
DC47003	Bevurogant	Bevurogant is a retinoid-related orphan receptor-gamma t (RORγt) antagonist. Bevurogant can be used for the research of chronic inflammatory diseases.
DC46880	Cedirogant	Cedirogant (ABBV-157) is an orally active RORγt inverse agonist. Cedirogant can be used for psoriasis research.
DC44172	RORγt inverse agonist 13	RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved drug-like properties, with an IC50 of 63.8 nM.
DC44171	RORγt Inverse agonist 6	RORγt Inverse agonist 6 (compound 43) is a RORγt inverse agonist for the study of Th17-driven autoimmune diseases. RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in vivo.
DC11846	TMP778	TMP778 (TMP-778) is a potent, selective RORγt inhibitor with IC50 of 7 nM in FRET assays and 63 nM in IL-17 promoter assays, with no inverse agonist activity.
DC11047	MRL871	MRL-871 (MRL871) is a potent, selective inhibitor of RORγt via allosteric inverse agonism, inhibits coactivator binding with IC50 of 7 nM; significantly reduces the IL17a mRNA levels in EL4 murine lymphoblast cell line at 10 uM.