RORγt inverse agonist 13|CAS 2170477-75-3|DC Chemicals

Cas No.:	2170477-75-3
Chemical Name:	RORgammat inverse agonist 13
Synonyms:	4-[[[[[2,6-Dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]amino]carbonyl]amino]methyl]benzeneacetic acid;RORγt inverse agonist 13;RORgammat inverse agonist 13;ROR;At inverse agonist 13;BDBM441828;AKOS040759911;2170477-75-3;2-[4-[[[3,5-dichloro-4-[2-(trifluoromethoxy)phenyl]phenyl]carbamoylamino]methyl]phenyl]acetic acid;CS-0133430;ROR??t inverse agonist 13;HY-131338;RORgamma t inverse agonist 13;CHEMBL4786768;EX-A5894;MS-29526;SCHEMBL20943259;US10647665, Example 1-15;G17729;ZBAVYJYWRYFFEJ-UHFFFAOYSA-N
SMILES:	ClC1C([H])=C(C([H])=C(C=1C1=C([H])C([H])=C([H])C([H])=C1OC(F)(F)F)Cl)N([H])C(N([H])C([H])([H])C1C([H])=C([H])C(C([H])([H])C(=O)O[H])=C([H])C=1[H])=O
Formula:	C₂₃H₁₇Cl₂F₃N₂O₄
M.Wt:	513.2933
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

COA

Cat. No.	Product name	Field of application
DC47003	Bevurogant	Bevurogant is a retinoid-related orphan receptor-gamma t (RORγt) antagonist. Bevurogant can be used for the research of chronic inflammatory diseases.
DC46880	Cedirogant	Cedirogant (ABBV-157) is an orally active RORγt inverse agonist. Cedirogant can be used for psoriasis research.
DC44172	RORγt inverse agonist 13	RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved drug-like properties, with an IC50 of 63.8 nM.
DC44171	RORγt Inverse agonist 6	RORγt Inverse agonist 6 (compound 43) is a RORγt inverse agonist for the study of Th17-driven autoimmune diseases. RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in vivo.
DC11846	TMP778	TMP778 (TMP-778) is a potent, selective RORγt inhibitor with IC50 of 7 nM in FRET assays and 63 nM in IL-17 promoter assays, with no inverse agonist activity.
DC11047	MRL871	MRL-871 (MRL871) is a potent, selective inhibitor of RORγt via allosteric inverse agonism, inhibits coactivator binding with IC50 of 7 nM; significantly reduces the IL17a mRNA levels in EL4 murine lymphoblast cell line at 10 uM.