DC73482 |
CVN766
|
CVN766 (CVN 766) is a potent, exquisitely selective orexin 1 receptor (OX1R) antagonist with IC50 of 8 nM, 1000-fold selective over OX2R. |
DC71983 |
Nivasorexant
|
Nivasorexant is a potent orexin receptor antagonist. |
DC28246 |
EMPA
|
EMPA is a high-affinity, reversible and selective orexin OX2 receptor antagonist. [3H]EMPA binds to human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectively. |
DC9573 |
SB-674042
|
SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM); exhibits 100-fold selectivity for OX1 over OX2 receptors.
|
DC7277 |
SB-408124
|
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively; exhibits 50-fold selectivity over OX2 receptor. |
DC8419 |
SB-334867
|
SB-334867 is a selective orexin-1 (OX1) receptor antagonist. |
DC7495 |
SB-334867 HCl
|
SB-334867 is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2. |
DC11439 |
Nemorexant
|
ACT-541468 is a dual orexin receptor antagonist. |