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GSK180

Cat. No.: DC70449

Chemical Structure

1799725-26-0

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Field of application

GSK180 (GSK-180) is a potent and specific inhibitor of kynurenine-3-monooxygenase (KMO) with IC50 of 6 nM, shows negligible activity against other enzymes on the tryptophan pathway; inhibits the convertion of kynurenine to 3-hydroxykynurenine with IC50 of 2.0 uM in cell-based assays; prevents multiple organ failure in rodent models of acute pancreatitis.

Chemicals Properties Biological activity COA & MSDS Related products Datasheet

Cas No.:	1799725-26-0
Chemical Name:	GSK180
Synonyms:	GSK 180;GSK-180
Formula:	C₁₀H₇Cl₂NO₄
M.Wt:	276.07
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC70449	GSK180	GSK180 (GSK-180) is a potent and specific inhibitor of kynurenine-3-monooxygenase (KMO) with IC50 of 6 nM, shows negligible activity against other enzymes on the tryptophan pathway; inhibits the convertion of kynurenine to 3-hydroxykynurenine with IC50 of 2.0 uM in cell-based assays; prevents multiple organ failure in rodent models of acute pancreatitis.
DC70127	GSK 065	A novel potent kynurenine-3-monooxygenase (KMO) inhibitor with IC50 of 4.5 nM.
DC70126	GSK 366	A novel potent kynurenine-3-monooxygenase (KMO) inhibitor with IC50 of 2.3 nM and 0.7 nM for human KMO and Pf-KMO, respectively.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.