GSK3482364|CAS 2170136-65-7|DC Chemicals

Cas No.:	2170136-65-7
Chemical Name:	GSK-3484862
Synonyms:	GSK-3484862;(2R)-2-[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide;BDBM491120;US10975056, Example 64;NSC825088;US10975056, Example 308;GSK3484862;(R)-2-((3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl)thio)-2-phenylacetamide;Gskmi-714;GSKMI-714;GSKMI-714;2170136-65-7;2170136-65-7;DA-53744;DA-53744;(R)-2-(3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-ylthio)-2-phenylacetamide;(R)-2-(3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-ylthio)-2-phenylacetamide;CS-0109599;CS-0109599;AKOS040733303;AKOS040733303;HY-135146;HY-135146;NSC-825088;NSC-825088;G17433;G17433;(2R)-2-{[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanyl}-2-phenylacetamide;(2R)-2-{[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanyl}-2-phenylacetamide;SCHEMBL19717424;SCHEMBL19717424;EN300-27187991;EN300-27187991;MS-25840;MS-25840
SMILES:	S(C1=C(C#N)C(=C(C#N)C(=N1)N(C)C)CC)[C@@H](C(N)=O)C1C=CC=CC=1
Formula:	C₁₉H₁₉N₅Os
M.Wt:	365.452061891556
Purity:	>98%
Sotrage:	GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity.

MSDS

Cat. No.	Product name	Field of application
DC73285	GSK3482364	GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity.
DC70865	UHRF1 PHD inhibitor MLD4	UHRF1 PHD inhibitor MLD4 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=12.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger.UHRF1 PHD inhibitor MLD4 inhibited binding between H3K9me3(FAM) and UHRF1 with IC50 of 24-26 uM, displace UHRF1-histone H3 binding in cells.