UHRF1 PHD inhibitor MLD4
Cat. No.: DC70865
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Chemical Structure
922067-76-3
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Field of application
UHRF1 PHD inhibitor MLD4 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=12.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger.UHRF1 PHD inhibitor MLD4 inhibited binding between H3K9me3(FAM) and UHRF1 with IC50 of 24-26 uM, displace UHRF1-histone H3 binding in cells.
| Cas No.: |
922067-76-3 |
| Chemical Name: |
UHRF1 PHD inhibitor MLD4 |
| Formula: |
C22H32N4O4 |
| M.Wt: |
416.522 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Publication: |
1. Wallace H Liu, et al. Biochemistry. 2022 Feb 10. |
| Description: |
UHRF1 PHD inhibitor MLD4 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=12.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger.UHRF1 PHD inhibitor MLD4 inhibited binding between H3K9me3(FAM) and UHRF1 with IC50 of 24-26 uM, displace UHRF1-histone H3 binding in cells. |
| References: |
1. Wallace H Liu, et al. Biochemistry. 2022 Feb 10. |
MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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