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H3B-960

Cat. No.: DC73189 Featured

Chemical Structure

2912294-89-2

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Field of application

H3B-960 is a potent, selective and covalent inhibitor of Werner syndrome protein (WRN) helicase activity with IC50 of 60 nM.

Cas No.:	2912294-89-2
Chemical Name:	H3B-960
SMILES:	O=C(NC1=CC=C(C)C=C1)CNS(=O)(C2=NC(C(F)(F)F)=CC(C3=CC=C(OC(F)(F)F)C=C3)=N2)=O
Formula:	C₂₁H₁₆F₆N₄O₄S
M.Wt:	534.43
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

Cat. No.	Product name	Field of application
DC73191	HRO761	HRO761 is a potent, selective, allosteric WRN inhibitor with IC50 of 100 nM (ATPase assay) and GI50 of 40 nM (SW48 cells), respectively. HRO761 binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation.
DC73189	H3B-960	H3B-960 is a potent, selective and covalent inhibitor of Werner syndrome protein (WRN) helicase activity with IC50 of 60 nM.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.