HRO761|CAS 2869954-34-5|DC Chemicals

Cas No.:	2869954-34-5
Chemical Name:	Werner syndrome RecQ helicase-IN-1
Synonyms:	[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo-;Werner syndrome RecQ helicase-IN-1
SMILES:	C12=NC(C3=CCOCC3)=NN1C(=O)C(N1CCN(C(C3C(O)=C(C)N=CN=3)=O)CC1)=C(CC)N2CC(NC1=CC=C(C(F)(F)F)C=C1Cl)=O
Formula:	C₃₁H₃₁ClF₃N₉O₅
M.Wt:	702.08335518837
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

Cat. No.	Product name	Field of application
DC73191	HRO761	HRO761 is a potent, selective, allosteric WRN inhibitor with IC50 of 100 nM (ATPase assay) and GI50 of 40 nM (SW48 cells), respectively. HRO761 binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation.
DC73189	H3B-960	H3B-960 is a potent, selective and covalent inhibitor of Werner syndrome protein (WRN) helicase activity with IC50 of 60 nM.
DC70162	A83B4C63	A83B4C63 is a highly potent small-molecule inhibitor targeting the DNA repair enzyme polynucleotide kinase 3'-phosphatase (PNKP), exhibiting strong binding affinity with a Kd of 80 nM. Due to its limited aqueous solubility, A83B4C63 was formulated into nano-encapsulated carriers, enhancing its therapeutic potential—particularly in PTEN-deficient colorectal cancer (CRC).