JNJ-67569762

  Cat. No.:  DC47721   Featured
Chemical Structure
2380313-26-6
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More than 5000 active chemicals with high quality for research!
Field of application
JNJ-67569762 is a tetrahydropyridine-based BACE1 inhibitor targeting the S3 pocket with IC50 of 2.7 nM and shows 71-fold selectivity over BACE2.
Cas No.: 2380313-26-6
Chemical Name: JNJ-67569762
Synonyms: 1,3-Dioxolo[4,5-c]pyridine-6-carboxamide, N-[3-[(2S,5R)-6-amino-5-(ethylsulfonyl)-2-(fluoromethyl)-2,3,4,5-tetrahydro-5-methyl-2-pyridinyl]-4-fluorophenyl]-2,2-difluoro-;JNJ-67569762
SMILES: C1=NC(C(NC2=CC=C(F)C([C@@]3(CF)N=C(N)[C@@](S(CC)(=O)=O)(C)CC3)=C2)=O)=CC2OC(F)(F)OC1=2
Formula: C22H22F4N4O5S
M.Wt: 530.49249792099
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_31571_DC47721_2380313-26-6
COA
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Cat. No. Product name Field of application
DC47721 JNJ-67569762 JNJ-67569762 is a tetrahydropyridine-based BACE1 inhibitor targeting the S3 pocket with IC50 of 2.7 nM and shows 71-fold selectivity over BACE2.
DC9901 Verubecestat (MK-8931) MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.
DC5053 LY2886721 LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease.
DC5180 LY2811376 LY2811376 is the first orally available non-peptidicβ-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM.
DC11551 Elenbecestat Elenbecestat (E2609) is a novel potent, oral BACE1 inhibitor for treatment of Alzheimer's disease..
DC11105 Umibecestat beta-secretase inhibitor.
DC8400 AZD3839 AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
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