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MRTX849 ethoxypropanoic acid

  Cat. No.:  DC46259  
Chemical Structure
2561529-98-2
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More than 5000 active chemicals with high quality for research!
Field of application
MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2. LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (DC50s between 0.25 and 0.76 μM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2561529-98-2
Chemical Name: NND-10046
Synonyms: Propanoic acid, 3-​[3-​[(2S)​-​2-​[[[7-​(8-​chloro-​1-​naphthalenyl)​-​4-​[(3S)​-​3-​(cyanomethyl)​-​4-​(2-​fluoro-​1-​oxo-​2-​propen-​1-​yl)​-​1-​piperazinyl]​-​5,​6,​7,​8-​tetrahydropyrido[3,​4-​d]​pyrimidin-​2-​yl]​oxy]​methyl]​-​1-​pyrrolidinyl]​
SMILES: C1=CC2C(=C(C=CC=2)Cl)C(N2CC3=C(CC2)C(=NC(=N3)OC[C@@H]2CCCN2CCCOCCC(=O)O)N2CCN([C@@H](CC#N)C2)C(=O)C(=C)F)=C1
Formula: C37H43ClFN7O5
M.Wt: 720.23
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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