| DC73117 |
BAY 1892005
|
BAY 1892005 is a small molecule that modulate mutant p53 condensation and nuclear accumulation, binds covalently to mutant p53R175H and p53Y220C and shows stabilization of p53WT and p53Y220C, exhibits anti-proliferative activity in a set of cell lines wit |
| DC42466 |
Amifostine thiol
|
Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine. Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway.
|
| DC8599 |
SP 141
|
SP 141 is a cell-permeable inhibitor of Mdm2 (Ki = 28 nM). |
| DC9506 |
SJ-172550
|
SJ-172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.
|
| DC8144 |
Pifithrin-β (hydrobromide)
|
Pifithrin-β HBr (Cyclic Pifithrin-α HBr) is a potent p53 inhibitor with IC50 of 23 uM in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1. |
| DC8454 |
Nutlin-3a
|
Nutlin-3a is arbitrarily referred to as enantiomer a because it appears as the first peak from chiral purification of racemic nutlin-3 and its absolute stereocenter assignment is not known. |
| DC3125 |
Nutlin-3
|
Nutlin 3 is a commercial available p53-MDM2 inhibitor, with Ki of 90 nM. |
| DC10957 |
MB725
|
MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM). |
| DC11726 |
Milademetan
|
Milademetan (DS-3032) is a specific and orally active MDM2 inhibitor for the research of acute myeloid leukemia (AML) or solid tumors. Milademetan (DS-3032) induces G1 cell cycle arrest, senescence and apoptosis. |
| DC11837 |
RO-5963
|
RO-5963 is an inhibitor of the interaction of both MDM2 and MDMX with p53. |
