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Nutlin-3

  Cat. No.:  DC3125   Featured
Chemical Structure
548472-68-0
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More than 5000 active chemicals with high quality for research!
Field of application
Nutlin 3 is a commercial available p53-MDM2 inhibitor, with Ki of 90 nM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 548472-68-0
Chemical Name: Nutlin-3
Synonyms: Nutlin-3;4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one;(+/-)-Nutlin-3;(±)-Nutlin-3;2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-;Nutlin (3);NUTLIN 3;Nutlin-3 (mixture)(Nutlin 3);2-Piperazinone,4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-,rel;Piperazinone,4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-,rel;(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one;nutlin-3A;Nutlin 3(Random Configuration);(+/-)-Nutlin3;4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one;MDM2 Antagonist, Nutlin-3, Racemic;4-({4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-o;Nutln 3A;Q27165473;BRD-A12230535-001-01-8;MFCD11977784;(+-)-4-[4,5-dihydro-imidazole-1-carbonyl]piperazin-2-one;4-[[4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone;(Rac)-Nutlin-3;MFCD14636430;SY283510;J-514247;CS-0007767;(+/-)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one;FT-0713388;FT-0771774;BCP02265;(??)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one;SW220144-1;the p53/MDM2 Agonist;AS-10121;(+)-Nutlin-3;H10266;AMY39899;Rac-Nutlin-3;BCP05161;SCHEMBL2458627;4-({4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one;SB19406;NSC-732664;AKOS005146527;FT-0773561;BDBM31197;MFCD07784509;Nutlin3;4-{[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazol-1-yl]carbonyl}-2-piperazinone;CHEBI:93777;HMS3651G03;s1061;CCG-264800;548472-68-0;SB19407;HMS3653F08;CHEMBL211045;(?)-Nutlin-3;890090-75-2;BCP29278;HY-10029A;NCGC00165848-01;HMS3653J08;NCGC00165848-02;nutlin 3;AC-35939;(-)-4-(4,5-bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl)piperazine-2-one;4-{[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5- dihydro-1H-imidazol-1-yl]carbonyl}-2-piperazinone;C30H30Cl2N4O4;FT-0700329;J-523776;A861337;4-[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one;EX-A851;SY289992;RG7112;R7112;rel-4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one;NSC732664;HMS3750A11;Z2159890360;Nutlin
SMILES: ClC1C([H])=C([H])C(=C([H])C=1[H])C1([H])C([H])(C2C([H])=C([H])C(=C([H])C=2[H])Cl)N=C(C2C([H])=C([H])C(=C([H])C=2OC([H])(C([H])([H])[H])C([H])([H])[H])OC([H])([H])[H])N1C(N1C([H])([H])C(N([H])C([H])([H])C1([H])[H])=O)=O
Formula: C30H30Cl2N4O4
M.Wt: 581.4896
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC73117 BAY 1892005 BAY 1892005 is a small molecule that modulate mutant p53 condensation and nuclear accumulation, binds covalently to mutant p53R175H and p53Y220C and shows stabilization of p53WT and p53Y220C, exhibits anti-proliferative activity in a set of cell lines wit
DC8599 SP 141 SP 141 is a cell-permeable inhibitor of Mdm2 (Ki = 28 nM).
DC9506 SJ-172550 SJ-172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.
DC8144 Pifithrin-β (hydrobromide) Pifithrin-β HBr (Cyclic Pifithrin-α HBr) is a potent p53 inhibitor with IC50 of 23 uM in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1.
DC8454 Nutlin-3a Nutlin-3a is arbitrarily referred to as enantiomer a because it appears as the first peak from chiral purification of racemic nutlin-3 and its absolute stereocenter assignment is not known.
DC3125 Nutlin-3 Nutlin 3 is a commercial available p53-MDM2 inhibitor, with Ki of 90 nM.
DC10957 MB725 MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM).
DC11726 DS-3032b DS-3032b is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity.
DC11837 RO-5963 RO-5963 is an inhibitor of the interaction of both MDM2 and MDMX with p53.
DC11669 CB-002 CB-002 is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts; increases expression of endogenous p53 target genes NOXA, DR5, and p21 and cell death; decreases the stability of mutant p53 in RXF393 cancer cells and an exogenously expressed R175H p53 mutant in HCT116 p53-null cells.
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