| Cas No.: | 511296-88-1 |
| Chemical Name: | Cyclic Pifithrin-α hydrobromide |
| Synonyms: | Cyclic Pifithrin-α hydrobromide;Cyclic Pifithrin-alpha Hydrobromide;Pifithrin-β hydrobromide;2-(4-Methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole hydrobromide;Cyclic Pifithrin-Alpha (Hydrobromide);Cyclic Pifithrin-α (hydrobromide);2-(4-Methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothia zole hydrobromide (1:1);2-(p-Tolyl)-5,6,7,8-tetrahydroimidazo[2,1-b]benzothiazole Hydrobromide;Cyclic PFT-α hydrobromide;PFT-β hydrobromide;2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole hydrobromide;Pifithrin-α, cyclic;QB102;Pifithrin-beta hydrobromide;Pifithrin-;A hydrobromide;Pifithrin-alpha, Cyclic-;UP003XXT4D;Cyclic Pifithrin-;2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr;2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole;hydrobromide;Pifithrin-beta hydrobromide [MI];Cyclic PFT-;cyclic-pifithrin |
| SMILES: | Br.CC1=CC=C(C=C1)C2=CN3C(SC4=C3CCCC4)=N2 |
| Formula: | C16H17BrN2S |
| M.Wt: | 349.2886 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Pifithrin-β is a potent p53 inhibitor with an IC50 of 23 μM. |
| Target: | IC50: 23 μM (p53)[1] |
| In Vitro: | Pifithrin-α, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β, the N-acetyl derivative[2]. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects[3]. |
| References: | [1]. Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19(5):1649-57. [2]. Fernández-Cruz ML, et al. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation productpifithrin-β. Life Sci. 2011 Apr 25;88(17-18):774-83. [3]. Da Pozzo E, et al. p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. ACS Chem Neurosci. 2014 May 21;5(5):390-9. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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| 2018-0101 |
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