| DC73482 |
CVN766
|
CVN766 (CVN 766) is a potent, exquisitely selective orexin 1 receptor (OX1R) antagonist with IC50 of 8 nM, 1000-fold selective over OX2R. |
| DC71983 |
Nivasorexant
|
Nivasorexant is a potent orexin receptor antagonist. |
| DC28246 |
EMPA
|
EMPA is a high-affinity, reversible and selective orexin OX2 receptor antagonist. [3H]EMPA binds to human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectively. |
| DC9573 |
SB-674042
|
SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM); exhibits 100-fold selectivity for OX1 over OX2 receptors.
|
| DC7277 |
SB-408124
|
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively; exhibits 50-fold selectivity over OX2 receptor. |
| DC8419 |
SB-334867
|
SB-334867 is a selective orexin-1 (OX1) receptor antagonist. |
| DC7495 |
SB-334867 HCl
|
SB-334867 is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2. |
| DC11439 |
Nemorexant
|
ACT-541468 is a dual orexin receptor antagonist. |
| DC73483 |
OBPt-9
|
OBPt-9 is a potent, postivie allosteric potentiator of orexin receptor-mediated signaling, similarly potentiates the response of OXR1 and OXR2 to orexin A. |
| DC73481 |
CVN45502
|
CVN45502 (CVN 45502) is a potent, orally bioavailable, highly selective orexin 1 receptor (Hcrtr1, OX1R) antagonist with binding affinity (pKi) of 7.86 (human Hcrtr1), significantly reduces feeding and body weight in diet-induced obese (DIO). |
