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PIM1-IN-1

Cat. No.: DC44020

Chemical Structure

1417630-95-5

For research use only. We do not sell to patients.

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Field of application

PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity.

Chemicals Properties Biological activity COA & MSDS Related products Datasheet

Cas No.:	1417630-95-5
Chemical Name:	PIM1-IN-1
SMILES:	COCCN1C2=C(C3=NN=C(C4=NC5=C(NCC6CCNCC6)C=CC=C5C=C4)N3N=C2)OCC1
Formula:	C₂₅H₃₀N₈O₂
M.Wt:	474.56
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47380	MNK/PIM-IN-1	MNK/PIM-IN-1 represents an innovative dual MNK/PIM inhibitor with a good pharmacokinetic profile.
DC45197	R8-T198wt	R8-T198wt is a cell-permeable carboxyl-terminal p27Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase.
DC44020	PIM1-IN-1	PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.