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T-1101 tosylate

  Cat. No.:  DC73200  
Chemical Structure
2250404-95-4
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Field of application
T-1101 tosylate (TAI-95 tosylate) is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=14.29-73.65 nM, breast cancer cell lines).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2250404-95-4
Chemical Name: T-1101 tosylate
Synonyms: TAI-95 tosylate
Formula: C31H31N5O6S3
M.Wt: 665.8
MSDS
Cat. No. Product name Field of application
DC73200 T-1101 tosylate T-1101 tosylate (TAI-95 tosylate) is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=14.29-73.65 nM, breast cancer cell lines).
DC73199 CCT241950 CCT241950 (CCT 241950) is a small molecule NEK2 inhibitor, induces Tyr70Nek2 to jut into the ADP-binding pocket.
DC70138 Nek2 inhibitor 3a A potent, relatively selective Nek2 inhibitor with IC50 of 82.74 nM in cell-free assays; inhibits only 3 kinases (YSK4, FLT3-ITDD835V and FLT3-ITDF691L) against 97 kinases with >65% inhibition at 15 nM; blocks NEK2-EZH2 complex formation and inhibits tumor cell proliferation; efficiently attenuates GBM growth in mouse model and exhibits a synergistic effect with radiotherapy.
DC70137 Nek2 inhibitor 11 A potent, ATP-competitive and relative selective Nek2 inhibitor with IC50 of 0.67 uM; displays >10-fold selectivity over CDK2.
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