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VY-3-135

  Cat. No.:  DC71165   Featured
Chemical Structure
1824637-41-3
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More than 5000 active chemicals with high quality for research!
Field of application
VY-3-135 is an orally active, selective acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 value of 44 nM. VY-3-135 displayes no inhibitory activity towards recombinant human ACSS1 or ACSS3. VY-3-135 potently inhibits ACSS2 dependent fatty acid metabolism but has no effect on gene expression in tumors. VY-3-135 inhibits triple negative breast cancer (TNBC) tumor growth in mouse ACSS2high but not ACSS2low tumors models.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1824637-41-3
Chemical Name: VY-3-135
Synonyms: 1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]-;VY-3-135
SMILES: C1(C(O)(C2=CC=CC=C2)C2=CC=CC=C2)N(CC)C2=CC(C(NC[C@H](O)C)=O)=CC=C2N=1
Formula: C26H27N3O3
M.Wt: 429.51
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_35391_DC71165_1824637-41-3
COA
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