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AG-946

Cat. No.: DC74247 Featured

Chemical Structure

2283422-04-6

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Field of application

AG-946 (AG946) is a potent, allosteric activator of wild-type and mutant RBC-specific form of pyruvate kinase (PKR) with AC50 of 5 nM for human wild-type PK, 4.3 nM and 6.9 nM for mutated K410E and R510Q PK proteins, resepctively.

Chemicals Properties Biological activity COA & MSDS Related products Datasheet

Cas No.:	2283422-04-6
Chemical Name:	PKR activator 2
SMILES:	C1=CC=C(N=C1N)CN1C(=O)C2N(C)C3N=C(CC4C=CNN=4)SC=3C=2C=N1
Formula:	C₁₈H₁₆N₈Os
M.Wt:	392.44
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

Cat. No.	Product name	Field of application
DC74247	AG-946	AG-946 (AG946) is a potent, allosteric activator of wild-type and mutant RBC-specific form of pyruvate kinase (PKR) with AC50 of 5 nM for human wild-type PK, 4.3 nM and 6.9 nM for mutated K410E and R510Q PK proteins, resepctively.
DC7942	ML-265	ML-265 activates tumor-specific PKM2 (EC50 = 92 nM) by binding to the dimer-dimer interface between two subunits of PKM2 and inducing tetramerization.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.