Cat. No. | Product name | CAS No. |
DC11387 |
Erdafitinib
Featured
Erdafitinib (JNJ-42756493) is a potent and orally available FGFR family inhibitor; inhibits FGFR1-4 with IC50 values of 1.2, 2.5, 3.0 and 5.7nM, respectively. |
1346242-81-6 |
DC8342 |
EW-7197
Featured
EW-7197 is a potent ALK5 inhibitor. EW-7197 showed potent in vivo anti-metastatic activity, indicating its potential for use as an anti-cancer therapy. |
1352608-82-2 |
DC2014 |
Flavopiridol
Featured
Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM, and CDK7 with IC50 of 300 nM. |
146426-40-6 |
DC8780 |
Flavopiridol Hydrochloride
Featured
Flavopiridol hydrochloride competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. |
131740-09-5 |
DC8164 |
Gilteritinib(ASP2215)
Featured
FLT3/AXL inhibitor |
1254053-43-4 |
DC8174 |
Pexmetinib(ARRY-614)
Featured
Pexmetinib is a potent Tie-2 and p38 MAPK dual inhibitor, with IC50s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38β, respectively, and can be used in the research of acute myeloid leukemia. |
945614-12-0 |
DC10485 |
GDC0575(ARRY-575,RG7441)
Featured
GDC0575(ARRY-575,RG7441)is a small molecule inhibitor of cell cycle checkpoint kinase 1 (Chk1), with potential chemosensitization activity. |
1196541-47-5 |
DC5147 |
Molibresib (I-BET-762)
Featured
GSK 525762A is a potent small molecule inhibitors that disrupt the function of the BET family of bromodomains (Brd2, Brd3, and Brd4). |
1260907-17-2 |
DC10647 |
EPZ015938(pemrametostat)
Featured
GSK3326595(EPZ015938) is the first-in-class protein arginine methyltransferase-5 (PRMT5) inhibitor. |
1616392-22-3 |
DC2070 |
GSK690693
Featured
GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively. |
937174-76-0 |
DC11262 |
IACS-010759
Featured
IACS-010759 (IACS010759) is a small molecule inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targets complex I of the mitochondrial electron transport chain. |
1570496-34-2 |
DC10174 |
Iberdomide
Featured
Iberdomide (CC-220) is a cereblon modulator in clinical development for systemic lupus erythematosis. Iberdomide exhibits an IC50 of 60 nM in TR-FRET cereblon binding assay. |
1323403-33-3 |
DC3130 |
ICG-001
Featured
ICG-001 is a small-molecule antagonist of b-catenin/TCF-mediated transcription (IC50 = 3 uM) and specifically downregulates the expression of a subset of b-catenin/TCF-responsive genes. ICG-001 binds specifically to cyclic AMP response element-binding pro |
780757-88-2 |
DC4181 |
Imatinib mesylate
Featured
Imatinib Mesylate is orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. |
220127-57-1 |
DC5072 |
Duvelisib (IPI-145, INK1197)
Featured
IPI-145 is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. |
1201438-56-3 |
DC12378 |
Itacitinib(INCB039110)
Featured
Itacitinib is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis. |
1334298-90-6 |
DC7067 |
KPT-330(Selinexor)
Featured
KPT-330, analog of KPT-185, is an orally bioavailable selective CRM1 inhibitor. |
1393477-72-9 |
DC8522 |
KW-2449
Featured
KW 2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. |
1000669-72-6 |
DC7449 |
KW-2478
Featured
KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. Phase 1/2 |
819812-04-9 |
DC9837 |
Larotrectinib (LOXO-101 sulfate)
Featured
LOXO-101 is a small molecule that was designed to block the ATP binding site of the TRK family of receptors, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases. |
1223405-08-0 |
DC8541 |
ORY-1001(Ladademstat)
Featured
ORY-1001 dihydrochloride (RG-6016, Ladademstat) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18 nM, displays high selectivity for KDM1A over other FAD-containing monoamine oxidases. |
1431303-72-8 |
DC6306 |
LY2157299(Galunisertib)
Featured
LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM. Phase 2. |
700874-72-2 |