RM133-3 is an ionizable lipid for potent functional mRNA delivery in vivo. The LPN formulation RM133-3-21, is found to be roughly 4.5 times more potent than DLin-MC3-DMA.

1,2-Distearoyl-sn-glycero-3-phosphorylglycerol is used as a component of a loposomal delivery system that coordinates the release of irinotecan and floxuridine in vivo. It is also used to encapsulate anthracyclines and deliver them to tumors.DSPG has a high transition temperature and has therefore found much use in liposomal drug delivery systems.

Lipid 10 is a novel ionizable cationic lipid be used for delivery of therapeutic RNA to the Bone Marrow in Multiple Myeloma Using CD38-Targeted with Lipid 10-LNP.

BIOTIN-11-DCTP is a fluorescent dye for DNA labeling.

306-N16B is a lipidnanoparticle, and allows systemic codelivery of Cas9 mRNA and sgRNA. 306-N16B can transport mRNA to the pulmonaryendothelial cell. 306-N16B can be used for research of genome editing-based therapies. Based on the same lipid libraries with 306-O12B, the researchers also found that N-series ionizable lipids were able to selectively deliver mRNA to the lungs of mice. Compared with the liver-targeted O-series ionizable lipids which contained ester bond in lipid tail found in previous work, such as 306-O12B, the N-series ionizable lipids with the lipid tail containing amide bond prefer to deliver mRNA to the lung. As a N-series ionizable lipid, the chemical structure of the 306-N16B is shown in Figure 4a,b. The difference of organ targeting may be due to their adsorption of different protein coronas during blood circulation caused by their different structures mentioned earlier.It has shown that the second major protein of the protein corona adsorbed by liver-targeting 306-O12B iLNPs was apolipoprotein E (ApoE), while the three dominant proteins in the protein corona adsorbed by lung-targeting 306-N16B iLNPs were serum albumin, fibrinogen beta chain, and fibrinogen gamma chain. However, the 306-N16B iLNPs showed less organ selectivity when systematically codelivered Cas9 mRNA and sgRNA in vivo, which could simultaneously activate tdTomato expression in the liver and lung of Ai14 mice, whereas single mRNA delivery could almost exclusively deliver mRNA to the lungs. This surprising phenomenon requires further investigation. Both the change of iLNPs charge and the change of lipids functional group can influence the distribution of iLNPs in vivo due to the altering of protein corona composition. Therefore, it is possible to control the organ targeting of iLNPs by controlling the composition of the outer protein corona of iLNPs.

AA-T3A-C12 is an anisamide ligand-tethered lipidoid (AA-lipidoid) with high potency and selectivity to deliver RNA payloads to activated fibroblasts. HSP47 siRNA (siHSP47)-loaded AA-T3A-C12 LNP achieves ~65% knockdown and dramatically reduces liver fibrosis, which significantly outperforms the benchmark DLin-MC3-DMA (MC3) LNP.

ALC-0315 analogue-2 is an analogue of ALC-0315. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine.

Lipid 6 is an ionizable amino lipid used for the generation of Lipid nanoparticles .

A2-Iso5-4DC19 is a lipidoid compound. A2-Iso5-4DC19 is an effective carrier for the delivery of an agent such as a polynucleotide to a cell.

Lipid 15 is an ionizable amino lipid used for the generation of Lipid nanoparticles .

LNP Lipid-5 (Compound Lipid 2) is an ionizable lipid (amino lipid). LNP Lipid-5 can be used to prepare lipid nanoparticles .

R6 is a new ionizable lipid driven from AI-Guided Ionizable Lipid Engineering (AGILE) platform for mRNA delivery. R6 LNPs exhibits a 5-fold increase in transfection potency in RAW 264.7 and shows its potential to be utilized for the development of non-viral mRNA delivery vectors for immune cells.

H9 is a new ionizable lipid driven from AI-Guided Ionizable Lipid Engineering (AGILE) platform for mRNA delivery. H9 LNPs shows superior mRNA transfection potency compared to LNPs containing (D-Lin-MC3-DMA).

C12-TLRa is an adjuvant lipidoid. C12-TLRa substitution can enhance the immunogenicity of clinically relevant SARS-CoV-2 mRNA-LNP vaccines, which holds translational potential.

ALC-0315 analgous-3 is an butanolamine ionizable lipid with both ester bonds located adjacent to C8 relative to the amine head. The introduction of ester linkages can improve the clearance of the lipid in the liver. This compound is analgous to ALC-0315.

BP Lipid 101 is an amino ionizable lipid analogous to SM-102. The ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C6 position relative to the amine nitrogen. The primary lipid tail has 7 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 102 is an ionizable lipid used to prepare lipid nanoparitlcels (LNPs). The lipid has ethanolamine as a lipid head group which enhances the mRNA encapsulation and provides exceptional physiochemical properties. Both esters of the lipid are at the C6 position relative to the amine. The lipid can be used for mRNA delivery. Reagent grade, for research purpose.

BP Lipid 103 is an amine ionizable lipid analogous to SM-102. The ethanolamine head improves encapsulation of mRNA. The lipid has both esters at C6 position relative to the amine nitrogen. Ester linkages in the lipid tails are introduced into the structure to improve tissue clearance. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research only.

BP Lipid 104 is an ionizable lipid with ethanolamine head to enhance mRNA encapsulation. Ester linkages at C7 position relative to amine are introduced into the structure to improve tissue clearance. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 105 is an ethanolamine ionizable lipid with 9 carbon of primary-ester lipid tail. The ethanolamine head helps with mRNA encapsulation. The ester bonds, located at C7 relative to amine nitrogen, improve tissue clearance. Reagent grade, for research purpose.

BP Lipid 106 is an amino ionizable lipid with ester bonds located at C7 relative to nitrogen. The ethanolamine head can effectively enhance mRNA encapsulation while ester bonds improve tissue clearance. The primary lipid tail contains 11 carbons. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose.

BP Lipid 107 is an ionizable amino lipid with both ester linkages located at C8 position relative to nitrogen amine. There is 7 carbons chain on the primary ester lipid tail. The secondary ester is introduced to improve protein expression. Reagent grade, for research purpose.

BP Lipid 109 is an amine lipid which has long (11 carbons) lipid tail on the primary ester. Both esters are located at C7 position and the head contains ethanolamine which can efficiently encapsulate mRNA. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose.

BP Lipid 110 is an ionizable amino lipid with ester likages located at C6 and C7 position relative to amine. The ethanolamine moiety can enhance encapsulation of mRNA. The lipid has a relatively short primary ester lipid tail (7C). Reagent grade, for research purpose.

BP Lipid 111 is an ionizable amine lipid with ethanolamine head for efficient mRNA encapsulation. The lipid has two ester linkages at C6 and C7 position. The C6 ester has a 9-carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 112 is an amine lipid with two ester linkages at C6 and C7 position. The C6 ester has a long 11 carbons lipid tail. The head of lipid is ethanolamine which can effectively encapsulate mRNA used in gene therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 113 is an ionizable lipid analogous to SM-102. The ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C6 and C8 position relative to the amine nitrogen. The primary ester at C6 position has a 7-carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 114 is an ethanolamine ionizable lipid with 9 carbon of primary-ester lipid tail. The ethanolamine head helps with mRNA encapsulation. The ester bonds are located at C6 and C8 position relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver. Reagent grade, for research purpose.

BP Lipid 116 is an ionizable amine lipid with ethanolamine head which can efficiently encapsulate mRNA. Ester linkages are incorporated, at C7 adn C6 position relative to amine, in the structure to increase tissue clearance of the lipid in the liver. The primary ester has a 7-carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 117 is an ethanolamine ionizable lipid with 9 carbon of primary-ester lipid tail. The ethanolamine head helps with mRNA encapsulation. The ester bonds, located at C7 and C6 relative to amine nitrogen, are introduced in the structure to improve tissue clearance. Reagent grade, for research purpose.

BP Lipid 118 is an amino ionizable lipid with ester bonds located at C7 and C6 poisiton relative to nitrogen. The ethanolamine head can effectively improve mRNA encapsulation while introduction of ester bonds improve tissue clearance. The primary ester contains a long 11 carbons tail. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose.

BP Lipid 119 is an ionizable amino lipid with both ester linkages located at C7 and C8 position relative to nitrogen amine. There is 7 carbons chain on the primary ester lipid tail. The ethanolamine head help encapsulation of mRNA while the introduction of secondary ester can improve protein expression. Reagent grade, for research purpose.

BP Lipid 120 is an amine lipid with two ester linkages at C7 and C8 position relative to the amine. The C7 ester has a medium length (9 carbons) lipid tail. The head of lipid is ethanolamine which can effectively encapsulate mRNA used in gene therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

Lipid 121 is an amino lipid which has a long (11 carbons) lipid tail on the primary ester located at C7 relative to nitrogen amine. The head contains ethanolamine which can efficiently encapsulate mRNA. The secondary ester is introduced, on the ester located at C8 position relative to amine, to improve protein expression in the liver. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose.

BP Lipid 122 is an ionizable amine lipid with ethanolamine head which can efficiently encapsulate mRNA. Ester linkages are incorporated in the structure at C8 adn C6 position relative to amine. These introduction of ester bonds can increase tissue clearance of the lipid in the liver. The primary ester at C8 poisition has a 7-carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 123 is an ionizable amino lipid with both ester linkages located at C8 and C6 position relative to nitrogen amine. There is 9 carbons chain on the primary ester lipid tail. The secondary ester is introduced to improve protein expression. The lipid head contains ethanolamine which can effectively encapsulate mRNA for gene therapies. Reagent grade, for research purpose.

BP Lipid 124 is an ethanolamine ionizable lipid with 11 carbon of primary-ester lipid tail. The ethanolamine head helps with mRNA encapsulation. The ester bonds are located at C8 and C6 position relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver. Reagent grade, for research purpose.

BP Lipid 125 is an ionizable lipid analogous to SM-102. The ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C8 and C7 position relative to the amine nitrogen. The primary lipid tail has 7 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 126 is an amino ionizable lipid with ester bonds located at C8 and C7 position relative to nitrogen. The ester linkages are introduced to improve tissue clearance. The ethanolamine head can effectively enhance mRNA encapsulation. The primary ester at C8 position contains 9 carbons lipid tail. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose.

BP Lipid 127 is an ethanolamine ionizable lipid with 11 carbons lipid tail attached on the primary-ester located at C8 position relative to amine. The second ester bond is located at C7 position relative to the amine nitrogen and has secondary ester lipid tail which can improve protein expression. The introduction of ester linkages can improve the clearance of the lipid in the liver. Reagent grade, for research purpose.

BP Lipid 210 is an ionizable lipid used to prepare lipid nanoparitlcels (LNPs). The lipid has ethanolamine as a lipid head group which enhances the mRNA encapsulation and provides exceptional physiochemical properties. The esters of the lipid are at the C10 and C8 position relative to the amine. The primary ester has a relatively long lipid tail (9 carbons). The lipid can be used for mRNA delivery. Reagent grade, for research purpose.

BP Lipid 209 is an amine lipid which has a 9-carbons lipid tail on the primary ester. Both esters are located at C8 and C10 position relative to the amine nitrogen. The head contains ethanolamine which can efficiently encapsulate mRNA. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose.

BP Lipid 213 is an amino lipid with ester bonds located at C10 and C8 position relative to nitrogen amine. The ethanolamine head can effectively enhance mRNA encapsulation while ester bonds improve tissue clearance. The primary lipid tail contains 11 carbons. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose.

BP Lipid 212 is an amino ionizable lipid analogous to BP-25499. The ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C8 and C10 position relative to the amine nitrogen. The primary ester has lipid a long 11-carbons tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 214 is an inonizable amine lipid with two ester linkages at C10 position relative to amine. The primary C10 ester has a long 11 carbons lipid tail. The head of lipid is ethanolamine which can effectively encapsulate mRNA used in gene therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 128 is an ionizable lipid analogous to SM-102. The propanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C6 position relative to the amine nitrogen. The primary lipid tail has 7 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 129 is an amine ionizable lipid used to prepare lipid nanoparitlcels (LNPs). The lipid has propanolamine as a lipid head group which enhances the mRNA encapsulation and provides exceptional physiochemical properties. Both esters of the lipid are at the C6 position relative to the amine. The lipid can be used for mRNA delivery. Reagent grade, for research purpose.

BP Lipid 130 is an ionizable amine lipid analogous to SM-102. The propanolamine head improves encapsulation of mRNA. The lipid has both esters at C6 position relative to the amine nitrogen. Ester linkages in the lipid tails are introduced into the structure to improve tissue clearance. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.BP Lipid 130 is an ionizable amine lipid analogous to SM-102. The propanolamine head improves encapsulation of mRNA. The lipid has both esters at C6 position relative to the amine nitrogen. Ester linkages in the lipid tails are introduced into the structure to improve tissue clearance. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 131 is an amino ionizable amine lipid with propanolamine head to enhance mRNA encapsulation. Ester linkages at C7 position relative to amine are introduced into the structure to improve tissue clearance. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 132 is a propanolamine ionizable lipid with 9 carbon of primary-ester lipid tail. The propanolamine head helps with mRNA encapsulation. The ester bonds, located at C7 relative to amine nitrogen, improve tissue clearance. Reagent grade, for research purpose.

C12-113 is a novel polyamine-derived lipidoid for gene delivery.

BP Lipid 133 is an amino ionizable lipid with ester bonds located at C7 relative to nitrogen. The propanolamine head can effectively enhance mRNA encapsulation while ester bonds improve tissue clearance. The primary lipid tail contains 11 carbons. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose.

BP Lipid 134 is an ionizable amino lipid with both ester linkages located at C8 position relative to nitrogen amine. There is 7 carbons chain on the primary ester lipid tail. The secondary ester is introduced to improve protein expression. Reagent grade, for research purpose.

BP Lipid 135 is an amino ionizable lipid with propanolamine lipid head which can improve mRNA encapsulation. The ester bonds are located at C8 position relative to nitrogen amine. There is 9 carbons chain on the primary ester lipid tail. The lipid can be used for preparation mRNA vesicle in gene therapy. Reagent grade, for research purpose.

BP Lipid 136 is an amino lipid which has long (11 carbons) lipid tail on the primary ester. Both esters are located at C7 position and the head contains propanolamine which can efficiently encapsulate mRNA. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose.

BP Lipid 137 is an ionizable amino lipid with ester likages located at C6 and C7 position relative to amine. The propanolamine moiety can enhance encapsulation of mRNA. The lipid has a relatively short primary ester lipid tail (7C). Reagent grade, for research purpose.

BP Lipid 138 is an ionizable amine lipid with propanolamine head for efficient mRNA encapsulation. The lipid has two ester linkages at C6 and C7 position. The C6 ester has a 9 carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 139 is an amine lipid with two ester linkages at C6 and C7 position. The C6 ester has a long 11 carbons lipid tail. The head of lipid is propanolamine which can effectively encapsulate mRNA used in gene therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 140 is an ionizable lipid analogous to SM-102. The propanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C6 and C8 position relative to the amine nitrogen. The primary ester at C6 position has a 7-carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 141 is a propanolamine ionizable lipid with ester bonds located at C6 and C8 relative to amine nitrogen. The ester linkages can improve tissue clearance. The ester at C6 position has a 9-carbon lipid tail. The propanolamine head helps with mRNA encapsulation. Reagent grade, for research purpose.

BP Lipid 142 is an ionizable amine lipid analogous to SM-102. The propanolamine head improves encapsulation of mRNA. The lipid has both esters at C6 and C8 position relative to the amine nitrogen. Ester linkages in the lipid tails are introduced into the structure to improve tissue clearance. The primary ester located at C6 is attached with a long (11-carbon) lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 143 is an ionizable amino lipid with propanolamine head which can efficiently encapsulate mRNA. Ester linkages are incorporated, at C7 adn C6 position relative to amine, in the structure to increase tissue clearance of the lipid in the liver. The primary ester has a 7-carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 144 is a propanolamine ionizable lipid with 9 carbon of primary-ester lipid tail. The propanolamine head helps with mRNA encapsulation. The ester bonds, located at C7 and C6 relative to amine nitrogen, are introduced in the structure to improve tissue clearance. Reagent grade, for research purpose.

BP Lipid 145 is an amino ionizable lipid with ester bonds located at C7 and C6 poisiton relative to nitrogen. The propanolamine head can effectively improve mRNA encapsulation while introduction of ester bonds improve tissue clearance. The primary ester contains a long 11 carbons tail. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose.

BP Lipid 146 is an ionizable amino lipid with both ester linkages located at C7 and C8 position relative to nitrogen amine. There is 7 carbons chain on the primary ester lipid tail. The propanolamine head help encapsulation of mRNA while the introduction of secondary ester can improve protein expression. Reagent grade, for research purpose.

BP Lipid 147 is an amine lipid with two ester linkages at C7 and C8 position relative to the amine. The C7 ester has a medium length (9 carbons) lipid tail. The head of lipid is propanolamine which can effectively encapsulate mRNA used in gene therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 148 is an amino lipid which has a long (11 carbons) lipid tail on the primary ester located at C7 relative to nitrogen amine. The head contains propanolamine which can efficiently encapsulate mRNA. The secondary ester is introduced, on the ester located at C8 position relative to amine, to improve protein expression in the liver. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose.

BP Lipid 149 is an ionizable amine lipid with propanolamine head which can efficiently encapsulate mRNA. Ester linkages are incorporated in the structure at C8 adn C6 position relative to amine. These introduction of ester bonds can increase tissue clearance of the lipid in the liver. The primary ester at C8 poisition has a 7-carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 150 is an ionizable amino lipid with both ester linkages located at C8 and C6 position relative to nitrogen amine. There is 9 carbons chain on the primary ester lipid tail. The secondary ester is introduced to improve protein expression. The lipid head contains propanolamine which can effectively encapsulate mRNA for gene therapies. Reagent grade, for research purpose.

BP Lipid 151 is a propanolamine ionizable lipid with 11 carbon of primary-ester lipid tail. The propanolamine head helps with mRNA encapsulation. The ester bonds are located at C8 and C6 position relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver. Reagent grade, for research purpose.

BP Lipid 152 is an ionizable lipid analogous to SM-102. The propanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C8 and C7 position relative to the amine nitrogen. The primary lipid tail has 7 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

BP Lipid 153 is an amino ionizable lipid with ester bonds located at C8 and C7 position relative to nitrogen. The ester linkages are introduced to improve tissue clearance. The propanolamine head can effectively enhance mRNA encapsulation. The primary ester at C8 position contains 9 carbons lipid tail. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose.

BP Lipid 154 is a propanolamine ionizable lipid with 11 carbons lipid tail attached on the primary-ester located at C8 position relative to amine. The second ester bond is located at C7 position relative to the amine nitrogen and has secondary ester lipid tail which can improve protein expression. The introduction of ester linkages can improve the clearance of the lipid in the liver. Reagent grade, for research purpose.

BP Lipid 226 is an amino ionizable lipid analogous to ALC-0315. The ethanolamine lipid head enhances encapsulation of mRNA. The lipid has identical ester bonds located adjacent to C6 relative to the amine nitrogen. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 216 is an amine lipid which has both ester bonds located adjacent to C7 relative to the nitogen amine. The head contains ethanolamine which can efficiently encapsulate mRNA. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 218 is an ionizable amine lipid with two identical ester tails adjacent to C6 position relative to amine. The head of lipid is propanolamine which can effectively encapsulate mRNA used in gene therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 219 is an amine ionizable lipid analogous to BP-25498 (ALC-0315). The propanolamine lipid head enhances encapsulation of mRNA. The lipid has identical ester bonds located adjacent to C7 relative to the amine nitrogen. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 220 is an amino lipid which has both ester bonds located adjacent to C8 relative to the nitogen amine. The head contains propanolamine which can efficiently encapsulate mRNA. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 221 is an ionizable amino lipid which has both ester bonds located adjacent to C7 relative to the nitogen amine. This lipid is an analogous to BP-25498/ALC-0315. The head contains butanolamine which can efficiently encapsulate mRNA. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 223 is an pentanolamine lipid with both ester bonds located adjacent to C6 relative to the amine head. The introduction of ester linkages can improve the clearance of the lipid in the liver. This compound is analgous to ALC-0315. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 224 is an amino ionizable lipid analogous to BP-25498/ALC-0315. The pentanolamine lipid head enhances encapsulation of mRNA. The lipid has identical ester bonds located adjacent to C7 relative to the amine nitrogen. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 400 is a cationic lipid-like compound containing a polar alcohol head group, two amides, four hydrophobic tails, and a tertiary amine linker. The lipoid can be formulated into a lipid nanoparticle (LNP) to deliver anionic substrates in vitro and in vivo. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 700 is a cationic lipid-like PEG compound containing a polar alcohol head group, four hydrophobic tails bound by esters, and a tertiary amine linker. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 800 is a cationic lipid-like PEG compound containing a polar alcohol head group, four hydrophobic tails bound by esters, and a tertiary amine linker. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 227 is an amino ionizable lipid. The ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C5 position relative to the amine nitrogen. The primary lipid tail has 8 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 1000 is an amino ionizable lipid. The ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C6 position relative to the amine nitrogen. The primary lipid tail has 8 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 229 is an amino ionizable lipid with an ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C8 position relative to the amine nitrogen. The lipid tails have 6 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

An analog of SM-102. The ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C7 position relative to the amine nitrogen. The primary lipid tail has 8 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle.

BP Lipid 306 is an amino ionizable lipid with an butanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C8 position relative to the amine nitrogen. The lipid tails have 8 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.

LNP Lipid-2 is a lipid product can be used to deliver agents.

SM-102 Analog 2(Compound 8-8) is a lipid compound. SM-102 Analog 2(Compound 8-8) is involved in the synthesis of lipid nanoparticles compositions. SM-102 Analog 2(Compound 8-8) has potential applications in the transportation of biologically active substances.

LNP Lipid-6 (Compound Lipid 5) is an ionizable lipid (amino lipid). LNP Lipid-6 can be used to prepare lipid nanoparticles (LNP).

Lipidoid XMaN6 is an ionizable lipid with universality was screened out from the adamantyl-based ionizable lipid series, which could functionally deliver highly diverse types of nucleic acids. Among them, the XMaN6 iLNPs were the best-delivering vectors. XMaN6 was used to deliver mRNA, siRNA, pDNA, and cyclic dinucleotide into different cells, including human primary hepatocytes, HEK293T, Huh7, HepG2, and U2OS cell, with nontoxicity after a single dose.The non-toxic XMaN6 lipidoid is highly versatile in entrapment and delivery of siRNA, mRNA, plasmid DNA, and a cyclic dinucleotide. XMaN6-based LNPs efficiently deliver: 1) siRNA into human primary hepatocytes and cell lines that are hard-to-transfect, 2) mRNA into mouse liver, 3) plasmid DNA, 4) 2′,3′-cGAMP into cells and activated the cGAS-STING pathway three orders of magnitude more efficiently than 2′,3′-cGAMP alone. To our knowledge, such universality in delivering different NA types has not been previously described and can accelerate translation of LNPs into the clinic.

ssPalmE-P4C2 contained vitamin E (α-tocopherol) as a hydrophobic scaffold instead of oleic acid. ssPalmE-P4C2 was reported to have the ability to deliver siRNA to the liver. LNPssPalmE-P4C2 and LNPssPalmO-P4C2 showed a comparable knockdown efficiency (15.4 ± 8.7% and 19.2 ± 4.4%, respectively).

Lipid 16 is an ionizable lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads. Lipid 16 as a potent cell type-specific ionizable lipid for the CD11bhi macrophage population without an additional targeting moiety.

Lipid 23 is an ionizable cationic amino lipid (pKa = 5.7) that has been used with other lipids in the formulation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing lipid 23 and encapsulating an mRNA reporter accumulate specifically in the mouse liver.

CL4F8-6 is an ionizable cationic lipid (pKa = 6.14) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs).1 Intravenous administration of LNPs containing CL4F8-6 and encapsulating an mRNA reporter accumulate specifically in the mouse liver. LNPs containing CL4F8-6 and encapsulating mRNA encoding the Cas9 nuclease (mCas9) and single-guide RNA (sgRNA) targeting Ttr (sgTtr), the gene encoding transthyretin, have been used to induce CRISPR-mediated gene knockdown in mice resulting in a reduction of serum levels of TTR.

1O14 is an ionizable cationic lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs).1 1O14-containing LNPs have been used for the delivery of IL-1β siRNA to induce gene silencing and hepatoprotective effects in a mouse model of acute liver injury induced by LPS and galactosamine (GalN).

ALC-0366 (III-45) is an ionizable cationic lipid (pKa = 6.25).It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1,2,3 LNPs containing lipid III-45 and encapsulating a luciferase mRNA reporter accumulate in liver and adipose tissue in mice.LNPs containing lipid III-45 have been used to deliver an mRNA sequence encoding an antibody targeting the tumor-associated antigen and tight junction integral protein claudin-18 isoform 2 (claudin-18.2) to mice and reduce tumor volume in an MDA-MB-231 mouse xenograft model.

SM-102 N-oxide is potential impurity in commercial preparations of SM-102.

DIM7S is a sugar-alcohol-derived ionizable lipid with mannitol as the precursor. DIM7S LNP is 10-fold, 30-fold, 20-fold, 4-fold and 3-fold superior in mRNA delivery than Lipo 3K, Electro, ALC-0315, MC3 and SM-102, respectively. DIM7S LNP enables effective CD40 mRNA delivery into human peripheral blood monocyte-derived DCs without obvious cytotoxicity.

LIS10W is a sugar-alcohol-derived ionizable lipid with L-sorbitol as the precursor. CD40L-LIS10W in the CATCH (CD40L-LIS10W+CD40-BDMCs) treatment simultaneously induces ICD and CD40L expressions in tumoural tissues, which enables to activate both endogenous DCs and adoptively transferred CD40-BMDCs.

C12-4 (C12-494,Lipid A-4) is a branched-chain ionizable cationic lipidoid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA. LNPs containing lipid A4 and encapsulating an mRNA reporter accumulate in the uterus, placenta, and ovaries, as well as to the spleen and liver, in pregnant mouse dams unlike LNPs containing the branched-chain ionizable cationic lipidoid C12-200, which primarily accumulate in the liver. Intravenous administration of LNPs containing lipid A4 and encapsulating mRNA encoding VEGF increase placental VEGFR1 levels and mean fetal blood vessel area without inducing liver damage in pregnant mouse dams.

IAJD93(IAJD-93) is a pentaerythritol-based one-component ionizable amphiphilic Janus Dendrimer (IAJD), delivery systems for mRNA delivery.

IAJD 288(IAJD-288) is a pentaerythritol-based one-component ionizable amphiphilic Janus Dendrimer (IAJD), delivery systems for mRNA delivery.

IAJD249(IAJD-249) is a pentaerythritol-based one-component ionizable amphiphilic Janus Dendrimer (IAJD), delivery systems for mRNA delivery.

CL1H6 is an ionizable lipid and CL1H6-LNP is capable of efficiently introducing both siRNA and mRNA into NK-92 cells.

Lipid 331 is a biodegradable cyclic ionizable lipid. LNPs containing Lipid 331 result in robust transfection in the nasal and lung tissues of mice and efficient transfection of lung epithelial cells and lung-resident APCs. Lipid 331 is a promising candidate for mRNA vaccine delivery, offering the potential for further enhancing the potency of mRNA vaccines.

GalNAc-L96 free base, the G-rich oligonucleotides carrying the longer GalNAc linker that can be used for delivery of nucleic acid drugs.

GalNac-L96 analog is an analog of GalNac-L96 used for siRNA delivery.

GalNac-L96, the G-rich oligonucleotides carrying the longer GalNAc linker that can be used for delivery of nucleic acid drugs[1].

C14-4 Core (Core 4) is the core structure of C14-4.

244-cis is an ionizable, liver-specific lipid. 244-cis LNP that induces lower immune responses than the responses evoked by previously used LNPs. 244-cis LNP and low-dose adeno-associated virus could minimize side effects and achieve a therapeutic threshold in hemophilia A mice.

76-O17Se is a lipidoid for the efficient delivery of antiCD19 mRNA CAR to murine primary macrophages. 76-O17Se is more efficient than delivery with lipofectamine 2000 (LPF2K) or MC3

9322-O16B is a lipidoid for the efficient delivery of antiCD19 mRNA CAR to murine primary macrophages. LNP 9322-O16B is more efficient than delivery with lipofectamine 2000 (LPF2K) or MC3.

LNP Lipid-8 (11-A-M) is an ionizable lipid, which can be used for lipid nanoparticles (LNP) to deliver siRNA to T cells without targeting to ligands. LNP LIPs-8 loaded with GFP siRNA (siGFP), and significantly causes GFP gene silencing in mice model.

cKK-E15 is an ionizable cationic lipid and a derivative of cKK-E12 that has been used in the generation of lipid nanoparticles (LNPs).1 LNPs containing cKK-E15 and encapsulating Cre mRNA induce the expression of Cre in Kupffer cells, endothelial cells, and hepatocytes in Ai14 mice engineered to express the fluorescent protein tdTomato upon translation of Cre.

306Oi9-cis2 is an ionizable cationic lipid. WARNING This product is not for human or veterinary use.

Lipid AX4 is an ionizable cationic lipid (pKa = 6.89) that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.

RM 137-15 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 LNPs containing RM 137-15 and encapsulating mRNA encoding a fluorescent reporter increase fluorescence in the livers of mice.

C12-SPM is a polyamine branched-chain lipidoid.1 It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of siRNA targeting the host protein kinase protein kinase C-related kinase 2 (PRK2) to inhibit hepatitis C virus (HCV) replication in Huh7 cells and a mouse model of HCV infection.

C14-SPM is a polyamine branched-chain lipidoid.1 It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of siRNA.

Lipid C14-A1 is an ionizable lipid. C14-A1-LPN is a potent and safe LNP platform to deliver Foxp3 mRNA to CD4+ T cells to engineer immunosuppressive FP3T cells.

Lipid C12-A1 is an ionizable lipid. C12-A1-LPN is a potent and safe LNP platform to deliver Foxp3 mRNA to CD4+ T cells to engineer immunosuppressive FP3T cells. C12-A1 has a slightly lower average cell viability than C14-A1.

Lipid 2-10 is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure.

RCB-4-8 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA.1 RCB-4-8-containing LNPs improve lung transfection efficiency by approximately 100-fold over MC3-containing LNPs in mice.

IR-19-Py(A20-0l) is an ionizable, degradable lipid for nebulized mRNA delivery.

IR-117-17(A10-LIN) is an ionizable, degradable lipid for nebulized mRNA delivery. Nebulized IR-117-17 LNPs produced a 300-fold improvement in lung mRNA delivery over the top previously described LNP. and a two-fold improvement over the previously reported PBAE, including up to a 45-fold improvement in delivery to the large airways.

4A3-SCC-10 is a biodegradable ionizable lipid with superior endosomal escape and rapid mRNA release ability. In comparison with DLin-MC3-DMA, 4A3-SCC-10-formulated LNPs significantly improve mRNA delivery in livers by 87-fold.

4A3-SCC-PH is a biodegradable ionizable lipid with superior endosomal escape and rapid mRNA release ability. In comparison with DLin-MC3-DMA, 4A3-SCC-PH-formulated LNPs significantly improve mRNA delivery in livers by 176-fold. 4A3-SCC-PH enhance Fluc mRNA release and luciferase expression in tumor cells, further assisting cancer metastasis delineation and surgical resection.

L-369 (Lipid 369,L369) is novel class of ionizable lipid for siRNA delivery with improved in vivo elimination profile with excellent translation across species,including NHP, wide safety margin.

Iso-A11B5C1 is an ionizable lipid. The iso-A11B5C1 LNP demonstrates a high level of muscle-specific mRNA delivery efficiency. exhibiting transfection efficiency comparable to the commercially available lipid SM-102, while considerably reducing inadvertent mRNA expression in main organs such as the liver and spleen.Additionally, study results show that intramuscular administration of mRNA formulated with iso-A11B5C1 LNP caused potent cellular immune responses, even with limited expression observed in lymph nodes.

DSPE-MPEG(5000) is a PEGylated form of 1,2-distearoyl-rac-glycero-3-PE (DSPE). It has been used in the synthesis of lipid nanoparticles (LNPs) and liposomes for in vitro and in vivo two-photon bioimaging.

DPPE is a derivative of phosphatidylethanolamine with (16:0) palmitoyl acyl chains

1-Palmitoyl-sn-glycero-3-phosphocholine is an abundant gonadal LPC (lysophosphatidylcholine).

1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for the preparation of liposomes and studying the properties of lipid bilayers.

DMPG is a phospholipid containing the saturated long-chain (14:0) myristic acid.

DSPA is a form of phosphatidic acid (PA) containing a phosphatidic acid head group and 18:0 fatty acids

DOPG-Na is a phospholipid containing the long-chain (18:1) fatty acid oleic acid inserted at the sn-1 and sn-2 positions. It can be used in the generation of micelles, liposomes, and other artificial membranes. DOPG is an anionic phospholipid derivative. The negatively charged liposomes prepared with DOPG has been found to possess the best loading capacity and encapsulation rate for Peptide Nucleic Acid (PNA) oligomers.

DPhPC is a phospholipid used to synthesize bilayer vesicles. DPhPC bilayers do not permit ions to leak in the absence of a pore/ion channel, which can be used for studies on channel proteins.

DPPA is a form of phosphatidic acid (PA).

18:0-18:2 PE is a lipid for agents delivering. 18:0-18:2 PE is mainly composed of unsaturated fatty acids. 18:0-18:2 is considered important precursors of important odorants (IOs) in Eriocheir sinensis.

POPE is a phospholipid, and can be used for drug delivery.

DOTAP mesylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

DLPA is a phosphatidic acid (PA) containing the medium-chain (12:0) lauric acid.

DLPE is a derivative of phosphatidylethanolamine with lauric acid (12:0) acyl chains.

DPyPE is a phosphatidylethanolamine lipid composed of polyisoprene alkyl chains. DPyPE is a co-lipid forvaxfectin mixed with GAP-DMORIE in a 1:1 ratio.

mPEG2000-DSPE is used in COVID 19 mRNA vaccines. It is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE . Formulations containing DSPE-MPEG(2000) have been used to prepare liposomes with long circulation time for the delivery of anticancer and antimalarial agents.. mPEG2000-DSPE has also been widely used as hydrophilic surface modifying agent for a variety types of hydrophobic nanoparticles, including recently reported lipid nanoparticle mRNA vaccines.

DPPG sodium is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Diheptanoyllecithin is a non-hydrolyzable analog.

514O6,10 is an ionizable lipidoid. 514O6,10 formulated LNPs facilitate mRNA delivery to the pancreas.

Lipid 20b is an ionizable lipid containing a thiophene moiety (Thio-lipid) for mRNA delivery. Lipid 20b enables LNPs to transfect the liver and spleen. Lipid 20b is potent in mRNA delivery to the retina with no acute toxicity.

C14-O2 is an oxidized lipid for mRNA delivery. C14-O2-LNP is capable of potent and selective delivery of mRNA to blood monocytes. C14-O2 LNP is used to deliver a functional CD19-CAR mRNA and is shown to engineer functional CAR monocytes directly in situ.

Lipid 29d is an ionizable lipid containing a thiophene moiety (Thio-lipid) for mRNA delivery. Lipid 29d enables LNPs to transfect the lung and spleen.

A1-28 is a disulfide bond-containing ionizable cationic lipid.1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for genome editing in vitro.

VL422 is an ionizable cationic lipid.1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for gene editing in vitro and in vivo. LNPs containing VL422 and encapsulating Cas9 mRNA and sgRNA targeting the gene encoding angiopoietin-related protein 3 (ANGPTL3), a protein whose loss-of-function decreases LDL, HDL, and cholesterol plasma levels, induce a deletion in a premature stop codon in ANGPTL3 in the livers of cynomolgus monkeys.

CL15F6 is an ionizable cationic lipid (pKa = 6.75).1 It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA and polymer-lipid hybrid nanoparticles for the delivery of plasmid DNA in vitro.1,2

C3-K2-E14 is an ionizable cationic lipid (pKa = 5.5).1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA or siRNA in vitro and in vivo. LNPs containing C3-K2-E14 and encapsulating siRNA targeting the gene encoding colony-stimulating factor 1 (Csf1) reduce the percentage of circulating Ly6Chi monocytes and increase the percentage of circulating Ly6Cint monocytes in mice.

(S)-C12-200 is an ionizable cationic lipid (pKa = 7.12) and an isomer of C12-200 (Item No. 36699).1 It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. Intravenous administration of LNPs containing (S)-C12-200 and encapsulating mRNA encoding Cre recombinase increase the percentage of tdTomato+ hepatocytes, endothelial cells, and Kupffer cells in the livers of Ai14 mice greater than (R)-C12-200-containing and Cre mRNA-encapsulating LNPs.

PPPDA-O16B is a disulfide bond-containing ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for plasmid delivery in vitro and in vivo.1 LNPs containing PPPDA-O16B and encapsulating plasmids encoding Ras/Rap1-specific endopeptidase (RRSP) increase RRSP levels and decrease Ras levels in, and reduce the viability of, HeLa cervical cancer cells. LNPs containing PPPDA-O16B and encapsulating plasmids encoding RRSP selectively localize to tumors over the heart, liver, spleen, lungs, and kidneys, as well as decrease tumor volume without reducing body weight, in an HCT116 colorectal cancer mouse xenograft model.

Lipid C3 is an ionizable cationic lipid (pKa = 5.05-5.671).1,2 It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 Intracerebroventricular administration of LNPs containing lipid C3 and encapsulating mRNA encoding α-L-iduronidase (Idua) to neonates increase midbrain and hippocampal α-L-iduronidase enzyme activity and decrease forebrain, midbrain, and hippocampal glycosaminoglycan levels in an Idua-W392X mouse model of the lysosomal storage disorder mucopolysaccharidosis type I, also known as Hurler syndrome. Intracerebroventricular administration of LNPs containing lipid C3 and encapsulating an mRNA reporter to fetal macaques in utero increase brain GFP expression.

BAmP-O16B is an ionizable cationic amino lipid that has been used in the generation of lipid nanoparticles (LNPs).1 LNPs containing BAmP-O16B and encapsulating NSA-inactivated RNase A reduce the viability of SiHa and HeLa cancer cells, but not non-cancerous NIH3T3 and HEK293T cells, upon intracellular reactivation of RNase A by glutathione (GSH).

Lipid OA2 is an ionizable cationic lipid that has been used in the generation of single-component lipid nanoparticles (LNPs) for the delivery of siRNA.1 LNPs containing lipid OA2 and siRNA targeting the gene encoding suppressor of cytokine signaling 1 (Socs1) decrease Socs1 expression by approximately 50% in isolated mouse bone marrow dendritic cells (BMDCs). Vaccination with ovalbumin-induced isolated mouse BMDCs transfected with LNPs composed of lipid OA2 and Socs1-targeting siRNA increases survival and decreases tumor volume in a B16-OVA murine melanoma model.

WLB-89462 (WLB89462) is a potent, highly selective sigma-2 receptor (σ2R) ligand with Ki of 13 nM, >100-fold selective over σ1R (Ki=1777 nM).

DB-lipidoid 11-10-8 is a degradable branched (DB) lipidoid. 11-10-8 LNP is more potent than MC3 LNP at delivering mRNA. 11-10-8 LNP enables roughly five-fold higher TTR genome editing efficiency and therapeutic FGF21 protein expression compared to MC3 LNP.

Lipid GVS-18-B6 is a silicon ether ionizable lipid for mRNA delivery. GVS-18-B6 showes particularly good liver specificity, with a liver-to-spleen EGFP signal ratio of 92:1. GVS-18-B6 also showes rapid tissue clearance within 6 hours of dosing.

Lipid CAD9 (3-A2-7b is a cationic degradable (CAD) lipid. 3-A2-7b formulated LNP, LNP-CAD9, can deliver FLuc mRNA to the lungs in vivo. LNP-CAD9 co-delivering Cas9 mRNA/VEGFR2 single guide RNA (sgRNA) effectively induces VEGFR2 knock out in lung endothelial cells of female mice.