| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC70237 | Bamocaftor potassium | Bamocaftor (VX-659) is a next-generation CFTR corrector, restores F508del-CFTR protein function. |
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| DC70796 | SRI-41315 Featured | SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion, restores CFTR expression and function, suppresses CFTR nonsense mutations.SRI-41315 induces translational readthrough by depleting eRF1 protein level and prolonging the translational pause that occurs at premature termination codons (PTCs).SRI-41315 reduced eRF1 levels in a manner dependent upon a ubiquitin-mediated proteasome degradation pathway.SRI-41315 in combination with G418 restores CFTR function in primary bronchial epithelial cells derived from a CF patient with CFTR nonsense alleles. |
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| DC72048 | SRI-37240 | SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418. |
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| DC72212 | CFTR corrector 8 | CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis. |
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| DC72358 | (R)-Olacaftor | (R)-Olacaftor ((R)-VX-440) is a Cystic fibrosis transmembrane conductance regulator (CFTR) modulator. (R)-Olacaftor has good potential for the study of cystic fibrosis (CF). |
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| DC72875 | GLPG2451 | GLPG2451 (GLPG 2451) is a potent potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 11 nM for F508del CFTR in the YHA assay and EC50 of 18 nM in TECC assay using HBE cells from patients carrying the F508del mutation. GLPG2451 improves the gating function of the CFTR channel. |
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