| DC42291 |
NSC 80467 |
NSC 80467, a DNA damaging agent, selectively inhibits survivin. NSC 80467 preferentially inhibits DNA synthesis and results in induction of γH2AX and pKAP1, two markers of DNA damage. |
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| DC42292 |
DENV-IN-2
Featured
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DENV-IN-2 is a potent dengue viral replication extracted from patent WO2018215315A1, compound 6AB, has an EC50 of 0.016 nM. DENV-IN-2 shows high potent activity against all four serotypes of the Dengue virus with EC50s ranging from 0.013 to 0.029 nM. |
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| DC42487 |
Datelliptium chloride hydrochloride |
Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from Ellipticine. Datelliptium chloride hydrochloride is effective in vivo against a variety of murine solid tumors. |
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| DC43967 |
Quinizarin |
Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the a |
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| DC43969 |
NITD-2
Featured
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NITD-2, a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly. |
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| DC44090 |
ddGTP |
ddGTP (2',3'-Dideoxyguanosine 5'-triphosphate) is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. |
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| DC44125 |
DMT-dC(bz) Phosphoramidite |
DMT-dC(bz) Phosphoramidite is typically used in the synthesis of DNA. |
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| DC44126 |
DMT-dT Phosphoramidite |
DMT-dT Phosphoramidite is typically used in the synthesis of DNA. |
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| DC44127 |
DMT-dU-CE Phosphoramidite |
DMT-dU-CE Phosphoramidite is a nucleoside molecule that can be used in DNA synthesis and DNA sequencing. |
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| DC44128 |
DMT-dG(ib) Phosphoramidite |
DMT-dG(ib) Phosphoramidite is typically used in the synthesis of DNA. |
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| DC44129 |
DMT-dA(bz) Phosphoramidite |
DMT-dA(bz) Phosphoramidite is typically used in the synthesis of DNA. |
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| DC44130 |
Deoxycytidine triphosphate trisodium salt |
Deoxycytidine triphosphate trisodium salt (dCTP trisodium salt) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate trisodium salt has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing. |
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| DC44131 |
7-Deaza-2'-deoxy-7-iodoadenosine |
7-Deaza-2'-deoxy-7-iodoadenosine is a modified oligonucleotide containing 7-Deazaadenine. |
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| DC44132 |
ddTTP |
ddTTP is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. |
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| DC44133 |
Deoxyguanosine triphosphate trisodium salt |
Deoxyguanosine triphosphate (dGTP) trisodium salt is a nucleotide precursor in cells for DNA synthesis. Deoxyguanosine triphosphate trisodium salt is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification. |
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| DC44134 |
ddCTP |
ddCTP is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. |
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| DC44135 |
5-Propargylamino-dCTP |
5-Propargylamino-dCTP is a nucleoside molecule extracted from patent US9035035B2, compound dCTP-PA. 5-Propargylamino-dCTP can conjugate to molecular markers for use in nucleic acid labeling or sequence analysis. |
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| DC44136 |
5-Propargylamino-ddCTP |
5-Propargylamino-ddCTP, a nucleoside molecule that can be used to synthesis of cyanine dye-nucleotide conjugate which is used in nucleic acid labeling or sequence analysis. |
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| DC44137 |
5-Propargylamino-ddUTP
Featured
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5-Propargylamino-ddUTP, a nucleoside molecule that can be used to synthesis of cyanine dye-nucleotide conjugate which is used in nucleic acid labeling or sequence analysis. |
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| DC44138 |
Thymidine-5'-triphosphate trisodium salt |
Thymidine-5'-triphosphate (dTTP) trisodium salt is one of the four natural deoxynucleotides. Thymidine-5'-triphosphate trisodium salt is used for the biosynthesis of deoxyribonucleic acid by DNA polymerase and reverse transcriptase. |
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| DC44845 |
4-Methoxyphenethyl alcohol |
4-Methoxyphenethyl alcohol, an aromatic alcohol, is the major component in the anise-like odour produced by A. albispathus Hett. 4-Methoxyphenethyl alcohol can inhibits the protein, RNA and DNA synthesis in Escherichia coli. |
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| DC44846 |
5'-O-DMT-dT |
5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative which can be used in the preparation of oligonucleotides. |
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| DC44847 |
5'-O-DMT-N4-Ac-dC |
5'-O-DMT-N4-Ac-dC (N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine, compound 7), a deoxynucleoside, can be used to synthesize of dodecyl phosphoramidite which is the raw material for dod‐DNA (amphiphilic DNA containing an internal hydrophobic region consisting of dodecyl phosphotriester linkages) synthesis. |
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| DC44848 |
Dmt-2'fluoro-da(bz) amidite |
Dmt-2'fluoro-da(bz) amidite, an uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotide, is a nuclease-resistant antisense compound with high affinity and specificity for RNA targets. Dmt-2'fluoro-da(bz) amidite is also an intermediate for 5’-DMT-3’-phosphoramidite synthesis. |
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| DC44849 |
8-NH2-ATP |
8-NH2-ATP, an inactive form of ATP, is produced by 8-NH2-Ado. 8-NH2-Ado is reported to be potent as shown by induction of apoptosis-related cleavage of poly (ADP-ribose) polymerase. |
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| DC44850 |
GC7 Sulfate |
GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.,DHPS [1]() |
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| DC44851 |
CHAPS
Featured
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CHAPS is a zwitterionic surfactant that decreases the sequence specificity of the nucleosome.,nucleosome [1]() |
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| DC45321 |
5-Iminodaunorubicin hydrochloride |
5-Iminodaunorubicin hydrochloride is a quinone-modified anthracycline that retains antitumor activity. 5-Iminodaunorubicin hydrochloride produces protein-concealed DNA strand breaks in cancer cells. |
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| DC45554 |
Aplidine
Featured
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Aplidine (Plitidepsin) is a potent anti-cancer agent by targeting eEF1A2 ( KD=80 nM). Aplidine possesses antiviral activity and is against SARS-CoV-2 with an IC90 of 0.88 nM. Aplidine is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research. |
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| DC45555 |
SCR130
Featured
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SCR130 is a novel DNA repair inhibitor with IC50s of 14 μM in Reh cells and 2 μM in Nalm6 cells. SCR130 specifically inhibits DNA Ligase IV‐mediated joining with minimal or no effect on Ligase III and Ligase I mediated joining. |
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