Cat. No. | Product name | CAS No. |
DC9790 |
Nazartinib(EGF816)
Featured
Nazartinib(EGF816) is a novel covalent inhibitor of mutant-selective EGFR; overcomes T790M-mediated resistance in NSCLC. |
1508250-71-2 |
DC7211 |
Neratinib (HKI-272)
Featured
Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR, respectively. |
698387-09-6 |
DC8078 |
PD 153035(AG-1517)
Featured
PD 153035(AG-1517) is an ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFRK), with an IC50 of 25 pM. |
153436-54-5 |
DC5021 |
PD153035 HCl (SU-5271, AG1517)
Featured
PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM; little effect noted against PGDFR, FGFR, CSF-1, InsR and Src. |
183322-45-4 |
DC7842 |
PD158780
Featured
PD158780 is a very potent inhibitor of EGFR with IC50 of 0.08 nM; pan-specific antagonist of ErbB receptor. |
171179-06-9 |
DC9258 |
PD168393
Featured
PD168393 is potent, cell-permeable, irreversible and selective inhibitor of EGF receptor (EGFR) tyrosine kinase and ErbB2. |
194423-15-9 |
DC7225 |
Pelitinib (EKB-569; WAY-EKB 569)
Featured
Pelitinib (EKB-569; WAY-EKB 569) is a potent irreversible EGFR inhibitor with IC50 of 38.5 nM. |
257933-82-7 |
DC11722 |
PF-06459988
PF-06459988 (PF06459988, PF 6459988) is a potent, selective, irreversible EGFR mutants with IC50 of 13, 7, 21 and 90 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively. |
1428774-45-1 |
DC1091 |
PF-299804 (Dacomitinib,PF-00299804)
Featured
PF299804 is a potent, irreversible pan-ErbB inhibitor against ErbB1, ErbB2 and ErbB4 with IC50 of 6 nM, 45.7 nM and 73.7 nM, respectively. |
1110813-31-4 |
DC11320 |
PF-6274484
PF-6274484 is an inhibitor of the EGF receptor (EGFR; IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively). |
1035638-91-5 |
DC7704 |
Poziotinib
Featured
Poziotinib, is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. |
1092364-38-9 |
DC9857 |
RG-13022
Featured
RG-13022 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 1 µM in HT-22 cells. |
136831-48-6 |
DC10367 |
RG14620
Featured
RG14620 is an epidermal growth factor receptor (EGFR) inhibitor, with IC50 values of 3 μM for HER 14 colony formation and 1 pM for HER 14 DNA synthesis. |
136831-49-7 |
DC10479 |
RX518(CK-101:EGFR-IN-3)
Featured
RX518(CK-101) is an orally available third-generation and selective inhibitor of certain epidermal growth factor receptor (EGFR) activating mutations. |
1660963-42-7 |
DC7078 |
AZD-8931(Sapitinib)
Featured
Sapitinib(AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM respectively. |
848942-61-0 |
DC10519 |
SU 5214
Featured
SU 5214 is a modulator of tyrosine kinase signal transduction. |
186611-04-1 |
DC7057 |
TAK-285
TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. |
871026-44-7 |
DC8557 |
AG879
Featured
Tyrphostin AG 879 is a protein tyrosine kinase inhibitor with potent effects on TrkA. |
148741-30-4 |
DC9775 |
WZ3146
Featured
WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I). |
1214265-56-1 |
DC5090 |
WZ4002
Featured
WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFR(L858R)/(T790M) with IC50 of 2 nM/8 nM; does not inhibit ERBB2 phosphorylation (T798I). |
1213269-23-8 |
DC3129 |
xl647
XL647 is a novel spectrum-selective kinase inhibitor for EGFR, ErbB2, KDR, Flt-4 and EphB4 with IC50 of 0.3 nM, 16 nM, 1.5 nM, 8.7 nM and 1.4 nM, respectively. |
781613-23-8 |
DC10764 |
Theliatinib (HMPL-309)
Featured
Theliatinib (HMPL-309) is a novel small molecule, EGFR tyrosine kinase inhibitor with potential antineoplastic and anti-angiogenesis activities. |
1353644-70-8 |