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Mobocertinib(TAK-788)

  Cat. No.:  DC28953   Featured
Chemical Structure
1847461-43-1
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More than 5000 active chemicals with high quality for research!
Field of application
Mobocertinib is a epidermal growth factor receptor (EGFR) inhibitor and an antineoplastic.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1847461-43-1
Chemical Name: TAK-788
Synonyms: AP-32788,AP32788,AP 32788,TAK 788,TAK788,TAK-788
SMILES: O=C(OC(C)C)C1C(C2C3C=CC=CC=3N(C)C=2)=NC(NC2C(OC)=CC(N(C)CCN(C)C)=C(NC(=O)C=C)C=2)=NC=1
Formula: C32H39N7O4
M.Wt: 585.69
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Francois Gonzalvez, et al. Abstract 2644: AP32788, a potent, selective inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, in preclinical models. April 16-20, 2016; New Orleans, LA.
Description: Mobocertinib is a potent epidermal growth factor receptor (EGFR) inhibitor and an antineoplastic agent, extracted from patent WO2019222093A1, compound A[1][2].
MSDS
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MSDS_13004_DC28953_1847461-43-1
COA
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Cat. No. Product name Field of application
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DC45317 EGFR/ErbB-2/ErbB-4 inhibitor-2 EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) is a EGFR and ErbB inhibitor with IC50s of 0.017 μM, 0.08 μM, 1.91 μM.
DC41015 BDTX-189 BDTX-189 is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, includes EGFR/HER2 exon 20 insertion mutants. BDTX-189 shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity.
DC28953 Mobocertinib(TAK-788) Mobocertinib is a epidermal growth factor receptor (EGFR) inhibitor and an antineoplastic.
DC28949 JBJ-04-125-02 JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M. JBJ-04-125-02 can inhibit cancer cell proliferation and EGFRL858R/T790M/C797S signaling. JBJ-04-125-02 has anti-tumor activities.
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