| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11226 | T1551 | T1551 is a novel selective PRMT5 inhibitor with IC50 of 34.1 uM, decreases cell viability of A549 cell with IC50 of 5.8 uM (72h). |
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| DC11703 | T-3775440 hydrochloride Featured | T-3775440 hydrochloride is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM. |
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| DC11702 | T-3775440 | T-3775440 is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM. |
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| DC7733 | Tasquinimod(ABR-215050) Featured | Tasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. |
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| DC1065 | Tenovin-1 Featured | Tenovin-1 is a p53 activator and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. |
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| DC7315 | Tenovin-6 Featured | Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 (IC50=21 uM) and SIRT2 (IC50= 10 uM) inhibitor as well as p53 activator. |
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| DC12487 | TH-34 Featured | TH34 is a potent HDAC6/8/10 inhibitor, induceing DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. |
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| DC8261 | (-)-JQ-1 Featured | The (-)-JQ1 stereoisomer has no appreciable affinity to BET bromodomains，it is the negative control of +JQ-1. |
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| DC10076 | Thiomyristoyl Featured | Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. |
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| DC10930 | Tianeptinaline | Tianeptinaline is a class I HDAC-selective, brain penetrant analogue of tianeptine with IC50 of 0.24, 0.12 and 0.155 uM for HDAC1, 2 and 3 respectively, does not inhibit HDAC6. |
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| DC10931 | Tianeptinostat | Tianeptinostat is a class I HDAC inhibitor with IC50 of 28, 33 and 51 nM for HDAC1, 2 and 3, respectively, also inhibits HDAC6 (IC50=1.6 nM) but not HDAC5 (IC50>80 uM). |
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| DC10478 | Tinostamustine(EDO-S101) Featured | Tinostamustine is the first representative of the A-DAC principle, a new approach in chemotherapy that uses fusion technology to combine an alkylating agent with a pan-histone deacetylase inhibitor (HDAC) to simultaneously damage DNA and block damage repa |
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| DC10210 | TMP195 Featured | TMP195 is the most potent and selective class IIa HDAC inhibitor. |
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| DC7716 | TMP269 Featured | TMP269 is a novel and selective class IIa histone deacetylase inhibitor with IC50s of 126/80/36/9 nM for HDAC 4/5/7/9, respectively; 20-400 fold selectivity over class1 HDACs. |
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| DC10190 | TPOP146 | TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4. |
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| DC8134 | Trichostatin A (TSA) Featured | Trichostatin A (TSA) is a selective and potent HDAC inhibitor with IC50 of ~1.8 nM; HDAC8 is the only known member of the HDAC-family that is not affected by TSA. |
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| DC5178 | Tubacin (BML-GR362) Featured | Tubacin is a selective inhibitor of HDAC6 via inhibition of the second deacetylase domain (DD2). |
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| DC6304 | Tubastatin A Featured | Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). |
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| DC6303 | Tubastatin A HCl Featured | Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). |
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| DC8663 | UF010 Featured | UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs. |
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| DC8293 | UNC-0224 Featured | UNC-0224 is a potent inhibitor of G9a histone lysine methyltransferase (IC50 = 15 nM). |
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| DC7915 | UNC0321 Featured | UNC0321 is a potent and selective G9a inhibitor with Ki of 63 pM, UNC0321 is the first G9a inhibitor with picomolar potency and the most potent G9a inhibitor to date.IC50 value: 63 pM(Ki); 9 nM (ECSD assay) [1]Target: G9aIt was found that replacing the 5- |
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| DC7671 | UNC0379 Featured | UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 with IC50 of 7.3±1.0 uM; selective over 15 other methyltransferases. |
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| DC7331 | UNC-0638 Featured | UNC0638 is an inhibitor of protein lysine methyltransferases G9a(IC50<15 nM) and GLP(IC50=19 nM) with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets. |
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| DC10024 | UNC-1079 Featured | UNC1079 is the piperidine analog of UNC1021, as a structurally similar but significantly less potent inhibitor for use as a negative control in cellular studies. |
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| DC7332 | UNC-1215 Featured | UNC1215 is a potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3 with Kd value of 120 nM. |
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| DC9965 | UNC3866 Featured | UNC3866 is a potent and selective antagonist of CBX4 and CBX7 chromodomains with (Kd ≈ 100 nM). It is 6- to 63-fold selective for these chromodomains over the other CBX and CDY chromodomains. |
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| DC8252 | Vorinostat (SAHA) Featured | Vorinostat (SAHA) is an HDAC1/3 inhibitor with IC50 of ~10 nM. |
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| DC8662 | WDR5-0103 Featured | WDR5-0103 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist with Kd of 450 nM. |
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| DC10881 | WM-1119 Featured | WM-1119(WM1119) is a highly potent, selective inhibitors of KAT6A and KAT6B. |
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