Cat. No. | Product name | CAS No. |
DC10023 |
MT-1
Featured
MT1 is a bivalent chemical probe of BET bromodomains.MT1 is an intramolecular bivalent BRD4 binder that is more than 100-fold more potent, in cellular assays, than the corresponding monovalent antagonist, JQ1. |
|
DC8823 |
XY1
Featured
Negative control of SGC 707. Exhibits >3000-fold lower potency (IC50 >100 μM) compared to the active analog. |
1624117-53-8 |
DC7548 |
Nexturastat A
Featured
Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM, >190-fold selectivity over other HDACs. |
1403783-31-2 |
DC9758 |
NI-57
Featured
NI-57 is a potent inhibitor of the bromodomains of BRPF proteins that binds to BRPF1B, BRPF2, and BRPF3 with Kd values of 31, 108, and 408 nM, respectively, as determined by isothermal titration calorimetry. |
1883548-89-7 |
DC7850 |
OF-1
Featured
OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain with Kd of 100 nM and 500 nM, respectively. |
919973-83-4 |
DC5204 |
OG-L002
Featured
OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively. |
1357302-64-7 |
DC9985 |
OICR9429
Featured
OICR-9429 is a potent and selective chemical probe suitable to help dissect the biological role of WDR5 (Kdisp < 100 nM). |
1801787-56-3 |
DC10658 |
OSS-128167(SIRT6-IN-1)
Featured
OSS-128167 is a novel SIRT6 inhibitor. |
887686-02-4 |
DC11257 |
OTS186935
Featured
OTS186935 (OTS-186935) is a potent, in vivo-active inhibitor of protein methyltransferase SUV39H2 with IC50 of 6.49 nM, inhibits A549 cell growth with IC50 of 0.67 uM; causes a significant growth inhibitory effect in mouse xenograft models using MDA-MB-231 breast cancer cells as well as A549 lung cancer cells, at 25 mg/kg once daily for 14 days yielded a TGI of 60.8%; attenuates the levels of H3K9me3 in A549 xenograft mouse model. |
2093400-18-9 |
DC11256 |
OTS193320
Featured
OTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM. |
2093401-33-1 |
DC7183 |
Panobinostat(LBH589)
Featured
Panobinostat(LBH-589) is a broad-spectrum HDAC inhibitor; low nanomolar concentrations (IC50=5-20 nM) of LBH589 induced cell-cycle arrest, apoptosis, and histone (H3K9 and H4K8) hyperacetylation in MOLT-4 and Reh cell. |
404950-80-7 |
DC1109 |
PCI-34051
Featured
PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM. |
950762-95-5 |
DC10634 |
PF-06726304
PF-06726304 is a selective EZH2 inhibitor with Ki values of 0.7 nM and 3 nM for WT EZH2 and Y641N respectively; also inhibits H3K27me3 with the IC50 value of 15 nM. |
1616287-82-1 |
DC11153 |
PF-06855800
PF-06855800 (PF06855800) is a potent, selective, SAM competitive, BBB-penetrant, orally active inhibitor of protein arginine methyltransferase PRMT5 with Ki of 0.02 nM. |
|
DC9305 |
PF-CBP1(PF-06670910) hydrochloride
Featured
PF-CBP1 is potent and highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) that down regulates targets of CBP in macrophages primary neurons. |
1962928-21-7 |
DC5025 |
PFI-1 (PF-6405761)
Featured
PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM. |
1403764-72-6 |
DC7679 |
(R)PFI-2 HCl
Featured
PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC50 ~2 nM. It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets. |
1627607-87-7 |
DC7649 |
PFI-3
Featured
PFI-3 is a novel potent, selective and cell permeable inhibitor of SMARCA4 and PB1(5) bromodomains with IC50 ~ 89 nM and 48 nM respectively. |
1819363-80-8 |
DC8291 |
PFI-4
Featured
PFI-4 is a potent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). |
900305-37-5 |
DC8661 |
Pimelic Diphenylamide 106(TC-H 106)
Featured
Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (HDAC 1, 2, and 3, with IC50 values of 150 nM , 760nM, and 370 nM, respectively), demonstrating no activity against class II HDACs. |
937039-45-7 |
DC10786 |
PLX51107
Featured
PLX51107 is a novel BET inhibitor with a unique binding mode in the acetylated lysine binding pocket of BRD4 that differentiates it from other compounds under investigation. |
1627929-55-8 |
DC7280 |
Pracinostat(SB939)
Featured
Pracinostat(SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6; has no activity against the class III isoenzyme SIRT I. |
929016-96-6 |