Cat. No. | Product name | CAS No. |
DC12248 |
PROTAC BET degrader-2
PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression. |
2093388-33-9 |
DC8654 |
PTACH (NCH-51)
Featured
PTACH (NCH-51) is a SAHA-based novel inhibitor of human HDAC. PTACH exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1 to 10 μM. |
848354-66-5 |
DC11041 |
QCA276
QCA276 is a novel potent BET proteins inhibitor with IC50/Ki of 10/.3 nM, QCA276 is the BET ligand for PROTAC QCA570. |
2126819-40-5 |
DC7176 |
Quisinostat (JNJ-26481585) 2HCl
Featured
Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11. |
875320-29-9 |
DC7037 |
R306465(JNJ-16241199)
Featured
R306465, also known as JNJ-16241199, is a novel hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models. |
604769-01-9 |
DC8646 |
Remodelin
Featured
Remodelin is an inhibitor of acetyl-transferase NAT10. |
949912-58-7 |
DC7796 |
Remodelin (hydrobromide)
Featured
Remodelin is an inhibitor of acetyl-transferase NAT10. |
1622921-15-6 |
DC7261 |
Resminostat hydrochloride (4SC-201)
Resminostat(RAS2410; 4SC-201) is a potent inhibitor of HDAC1/3/6(IC50=43-72 nM); less potent to HDAC8 with IC50 of 877 nM. |
1187075-34-8 |
DC7795 |
RG2833 (RGFP109)
Featured
RG2833 is a brain-penetrant inhibitor of HDAC with IC50 values of 60 nM and 50 nM for HDAC1 and HDAC3, respectively. |
1215493-56-3 |
DC7263 |
RGFP 966
Featured
RGFP966 is specific inhibitor of HDAC3, with an IC50 of 0.08 μM and no effective inhibition of any other HDAC at concentrations up to 15 μM. |
1357389-11-7 |
DC7636 |
RN-1 Hydrochloride
Featured
RN-1 is an inhibitor of lysine specific demethylase 1 (LSD1); exhibits selectivity for LSD1 over monoamine oxidase (MAO)-A and MAO-B (IC50 values are 70 nM, 0.51 and 2.79 μM respectively. |
1781835-13-9 |
DC7048 |
Ricolinostat (ACY-1215)
Featured
Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM; >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2. |
1316214-52-4 |
DCAPI1434 |
Romidepsin(FK-228)
Featured
Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively. |
128517-07-7 |
DC8839 |
RS-1
Featured
RS-1 is a stimulator of the human homologous recombination protein RAD51,enhances homology-directed repair ~2 to 5-fold and increases CRISPR-mediated knock-in efficiencies in vitro and in vivo. |
312756-74-4 |
DC8320 |
RVX-208
Featured
RVX-208(RVX 000222) is a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo; is a BET bromodomain antagonist. |
1044870-39-4 |
DC10002 |
Salermide
Featured
Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death. In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~ 20 μM) by reactivating proapototic genes that are repressed by SIRT1. |
1105698-15-4 |
DC11014 |
SALL4 peptide FFW
Featured
SALL4 peptide FFW (RRKFAKFQWI, FFW peptide) is a potent therapeutic SALL4 peptide antagonist of SALL4-NURD (nucleosome remodeling deacetylase) interaction with target affinity of 23 nM. |
|
DC7284 |
Scriptaid(GCK1026)
Featured
Scriptaid(Scriptide; GCK-1026) is an inhibitor of HDAC; shows a greater effect on acetylated H4 than H3. |
287383-59-9 |
DC11400 |
Seclidemstat(SP-2577)
Featured
Seclidemstat(SP-2577) is a potent LSD1 inhibitor, with a mean IC50 of 127 nM. |
1423715-37-0 |
DC8061 |
SGC-707
Featured
SGC 707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 31 nM). |
1687736-54-4 |
DC10429 |
SGC2085
Featured
SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC50 of 50 nM. |
1821908-48-8 |
DC7293 |
SGI-1027
Featured
SGI-1027 is a potent and selective inhibitor of DNA methyltransferase (DNMT) with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B, respectively. |
1020149-73-8 |