| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC7037 | R306465(JNJ-16241199) Featured | R306465, also known as JNJ-16241199, is a novel hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models. |
|
| DC8646 | Remodelin Featured | Remodelin is an inhibitor of acetyl-transferase NAT10. |
|
| DC7796 | Remodelin (hydrobromide) Featured | Remodelin is an inhibitor of acetyl-transferase NAT10. |
|
| DC7261 | Resminostat hydrochloride (4SC-201) | Resminostat(RAS2410; 4SC-201) is a potent inhibitor of HDAC1/3/6(IC50=43-72 nM); less potent to HDAC8 with IC50 of 877 nM. |
|
| DC7795 | RG2833 (RGFP109) Featured | RG2833 is a brain-penetrant inhibitor of HDAC with IC50 values of 60 nM and 50 nM for HDAC1 and HDAC3, respectively. |
|
| DC7263 | RGFP 966 Featured | RGFP966 is specific inhibitor of HDAC3, with an IC50 of 0.08 μM and no effective inhibition of any other HDAC at concentrations up to 15 μM. |
|
| DC7636 | RN-1 Hydrochloride Featured | RN-1 is an inhibitor of lysine specific demethylase 1 (LSD1); exhibits selectivity for LSD1 over monoamine oxidase (MAO)-A and MAO-B (IC50 values are 70 nM, 0.51 and 2.79 μM respectively. |
|
| DC7048 | Ricolinostat (ACY-1215) Featured | Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM; >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2. |
|
| DCAPI1434 | Romidepsin（FK-228） Featured | Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively. |
|
| DC8839 | RS-1 Featured | RS-1 is a stimulator of the human homologous recombination protein RAD51,enhances homology-directed repair ~2 to 5-fold and increases CRISPR-mediated knock-in efficiencies in vitro and in vivo. |
|
| DC8320 | RVX-208 Featured | RVX-208(RVX 000222) is a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo; is a BET bromodomain antagonist. |
|
| DC10002 | Salermide Featured | Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death. In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~ 20 μM) by reactivating proapototic genes that are repressed by SIRT1. |
|
| DC11014 | SALL4 peptide FFW Featured | SALL4 peptide FFW (RRKFAKFQWI, FFW peptide) is a potent therapeutic SALL4 peptide antagonist of SALL4-NURD (nucleosome remodeling deacetylase) interaction with target affinity of 23 nM. |
|
| DC7284 | Scriptaid(GCK1026) Featured | Scriptaid(Scriptide; GCK-1026) is an inhibitor of HDAC; shows a greater effect on acetylated H4 than H3. |
|
| DC11400 | Seclidemstat（SP-2577） Featured | Seclidemstat(SP-2577) is a potent LSD1 inhibitor, with a mean IC50 of 127 nM. |
|
| DC8061 | SGC-707 Featured | SGC 707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 31 nM). |
|
| DC10429 | SGC2085 Featured | SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC50 of 50 nM. |
|
| DC7293 | SGI-1027 Featured | SGI-1027 is a potent and selective inhibitor of DNA methyltransferase (DNMT) with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B, respectively. |
|
| DC6313 | Guadecitabine（SGI-110） Featured | SGI-110 (S-110) is a stable and potent inhibitor for DNA methylation, inhibits DNMT1 when SGI-110 is activated by phosphorylation and incorporated into DNA. |
|
| DC8867 | SirReal2 | SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. |
|
| DC7539 | SIRT2 Inhibitor II, AK-1 Featured | SIRT2 Inhibitor II, AK-1 inhibits SIRT2 selectively over SIRT1 and SIRT3. |
|
| DC12109 | SIRT5 inhibitor | SIRT5 inhibitor is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM. |
|
| DC7956 | SP2509 Featured | SP2509 is a novel histone demethylase LSD1 (KDM1A) antagonist with IC50 of 13 nM; no inhibition on MAO-A and MAO-B. |
|
| DC7673 | Splitomicin Featured | Splitomicin is a derivative of β-naphthol is an inhibitor of Silent Information Regulator 2 (SIR2). |
|
| DC10788 | SR-4370 Featured | SR-4370 is an HDAC inhibitor. SR-4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. |
|
| DC8900 | SRT1720 Featured | SRT1720 is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 μM；SIRT3: EC1.5 > 300 μM). |
|
| DC7300 | SRT1720 HCl Featured | SRT1720 is a selective SIRT1 activator with EC50 of 0.16 μM, but is >230-fold less potent for SIRT2 and SIRT3. |
|
| DC8412 | SRT2104 Featured | SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2. |
|
| DC11156 | SRTCX1002 | SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay. |
|
| DC11157 | SRTCX1003 | SRTCX1003 (SRTCX-1003) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.61 uM, enhances deacetylation of cellular p65 protein with IC50 of 1.42 uM in cellular p65 acetylation assay. |
|
